Literature DB >> 3495457

Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C.

M Abrahamson, A Grubb, I Olafsson, A Lundwall.   

Abstract

Recombinant cystatin C producing clones were isolated from a human placenta lambda gt11 cDNA library. The cDNA insert of one of the clones, containing 777 base pairs, encodes the complete mature cystatin C (120 amino acids) and a hydrophobic leader sequence of 26 amino acids, indicating an extracellular function of the inhibitor. The deduced protein sequence confirms the protein sequence of cystatin C isolated from human urine, but differs in one position from the sequence of the cystatin C fragment deposited as amyloid in hereditary cerebral hemorrhage with amyloidosis.

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Year:  1987        PMID： 3495457     DOI： 10.1016/0014-5793(87)80695-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

Review 1.  Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.

Authors:  R H H van den Heuvel; B Curti; M A Vanoni; A Mattevi
Journal:  Cell Mol Life Sci       Date:  2004-03       Impact factor: 9.261

2.  SstII polymorphic sites in the promoter region of the human cystatin C gene.

Authors:  M Balbín; M Abrahamson
Journal:  Hum Genet       Date:  1991-10       Impact factor: 4.132

3.  Three RFLPs at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland.

Authors:  A Palsdottir; S Jonsdottir; M Abrahamson; A Grubb; O Jensson
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

4.  Structure and expression of the human cystatin C gene.

Authors:  M Abrahamson; I Olafsson; A Palsdottir; M Ulvsbäck; A Lundwall; O Jensson; A Grubb
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

5.  Stabilized Human Cystatin C Variant L47C/G69C Is a Better Reporter Than the Wild-Type Inhibitor for Characterizing the Thermodynamics of Binding to Cysteine Proteases.

Authors:  David O Tovar-Anaya; L Irais Vera-Robles; M Teresa Vieyra-Eusebio; Ponciano García-Gutiérrez; Francisco Reyes-Espinosa; Andrés Hernández-Arana; J Alfonso Arroyo-Reyna; Rafael A Zubillaga
Journal:  Protein J       Date:  2019-10       Impact factor: 2.371

6.  An extracellular insoluble inhibitor of cysteine proteinases in cell cultures and seeds of carrot.

Authors:  A Ojima; H Shiota; K Higashi; H Kamada; Y Shimma; M Wada; S Satoh
Journal:  Plant Mol Biol       Date:  1997-05       Impact factor: 4.076

7.  Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion.

Authors:  Doan H Nguyen; Hiroshi Toshida; Jill Schurr; Roger W Beuerman
Journal:  Physiol Genomics       Date:  2004-06-17       Impact factor: 3.107

8.  Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease.

Authors:  Roberta Ghidoni; Anna Paterlini; Valentina Albertini; Michela Glionna; Eugenio Monti; Luisa Schiaffonati; Luisa Benussi; Efrat Levy; Giuliano Binetti
Journal:  Neurobiol Aging       Date:  2009-09-20       Impact factor: 4.673

9.  Increased body temperature accelerates aggregation of the Leu-68-->Gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy.

Authors:  M Abrahamson; A Grubb
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

10.  Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis.

Authors:  M Abrahamson; S Jonsdottir; I Olafsson; O Jensson; A Grubb
Journal:  Hum Genet       Date:  1992-06       Impact factor: 4.132
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