Literature DB >> 3495448

Calcitonin gene-related peptide is a potent relaxant of intestinal muscle.

L Barthó, F Lembeck, P Holzer.   

Abstract

The motor effects of calcitonin gene-related peptide (CGRP) on the guinea-pig ileum (GPI) longitudinal muscle were investigated. CGRP (0.1-100 nM) concentration dependently relaxed ilea precontracted with histamine and inhibited electrically induced cholinergic contractions. At higher concentrations (3-100 nM) CGRP also caused a slight contraction of non-stimulated ilea. Further pharmacological analysis of the CGRP-induced relaxation which seems to be the primary CGRP effect in the GPI, indicated that the effect was due to a direct action on the longitudinal muscle.

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Year:  1987        PMID： 3495448     DOI： 10.1016/0014-2999(87)90699-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Developmentally regulated expression of calcitonin gene-related peptide at mammalian neuromuscular junction.

Authors:  M Matteoli; S Balbi; C Sala; B Chini; M Cimino; M Vitadello; G Fumagalli
Journal:  J Mol Neurosci       Date:  1990       Impact factor: 3.444

2.  Calcitonin gene-related peptide-like immunoreactive cells in the secretory portions of rat sweat glands.

Authors:  A Ishida-Yamamoto; M Tohyama
Journal:  Cell Tissue Res       Date:  1990-05       Impact factor: 5.249

3.  Immunohistochemical evidence suggests intrinsic regulatory activity of human eccrine sweat glands.

Authors:  C Zancanaro; F Merigo; C Crescimanno; S Orlandini; A Osculati
Journal:  J Anat       Date:  1999-04       Impact factor: 2.610

4.  Human isolated small intestine: motor responses of the longitudinal muscle to field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; P Beneforti; D Misuri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

5.  Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; A Giachetti; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

Review 6.  Acid-sensing pathways in rat gastrointestinal mucosa.

Authors:  Yasutada Akiba; Masahiko Nakamura; Hiroshi Nagata; Jonathan D Kaunitz; Hiromasa Ishii
Journal:  J Gastroenterol       Date:  2002-11       Impact factor: 7.527

7.  Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog.

Authors:  D C Lawson; C R Mantyh; T N Pappas
Journal:  Dig Dis Sci       Date:  1994-07       Impact factor: 3.199

8.  Action of histamine on nerve mediated responses of the guinea-pig ileum.

Authors:  O Matusák; V Bauer
Journal:  Agents Actions       Date:  1988-04

9.  Cyclic AMP-mediated regulation of excitation-contraction coupling in canine gastric smooth muscle.

Authors:  H Ozaki; D P Blondfield; M Hori; K M Sanders; N G Publicover
Journal:  J Physiol       Date:  1992-02       Impact factor: 5.182
  9 in total

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