Jason José Bendezú1, Michelle Thai2, Andrea Wiglesworth2, Kathryn R Cullen3, Bonnie Klimes-Dougan2. 1. The Institute of Child Development, University of Minnesota, Minneapolis, MN 55455, United States; Department of Psychology, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: bende369@umn.edu. 2. Department of Psychology, University of Minnesota, Minneapolis, MN 55455, United States. 3. Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55455, United States.
Abstract
BACKGROUND: Dysregulated stress responsivity is implicated in adolescent risk for depression and self-injurious thoughts and behaviors (STBs). However, studies often examine levels of the stress response in isolation, precluding understanding of how coordinated disturbance across systems confers risk. The current study utilized a novel person-centered approach to identify stress correspondence profiles and linked them to depressive symptoms, STBs, and neural indices of self-regulatory capacity. METHOD: Adolescents with and without a major depressive disorder diagnosis (N = 162, Mage = 16.54, SD = 1.96, 72.8% White, 66.5% female) completed the Trier Social Stress Test (TSST), questionnaires, and clinical interviews. Stress experience (self-report), expression (observed), and physiology (salivary cortisol) were assessed during the experimental protocol. Adolescents also underwent a magnetic resonance imaging scan. RESULTS: Multitrajectory modeling revealed four profiles. High Experience-High Expression-Low Physiology (i.e., lower stress correspondence) adolescents were more likely to report depressive symptoms, lifetime nonsuicidal self-injury, and suicidal ideation relative to all other subgroups reflecting higher stress correspondence: Low Experience-Low Expression-Low Physiology, Moderate Experience-Moderate Expression-Moderate Physiology, High Experience-High Expression-High Physiology. High Experience-High Expression-Low Physiology adolescents also exhibited less positive amygdala-ventromedial prefrontal cortex resting state functional connectivity relative to Moderate Experience-Moderate Expression-Moderate Physiology. LIMITATIONS: Data were cross-sectional, precluding inference about our profiles as etiological risk factors or mechanisms of risk. CONCLUSIONS: Findings illustrate meaningful heterogeneity in adolescent stress correspondence with implications for multimodal, multilevel assessment and outcome monitoring in depression prevention and intervention efforts.
BACKGROUND: Dysregulated stress responsivity is implicated in adolescent risk for depression and self-injurious thoughts and behaviors (STBs). However, studies often examine levels of the stress response in isolation, precluding understanding of how coordinated disturbance across systems confers risk. The current study utilized a novel person-centered approach to identify stress correspondence profiles and linked them to depressive symptoms, STBs, and neural indices of self-regulatory capacity. METHOD: Adolescents with and without a major depressive disorder diagnosis (N = 162, Mage = 16.54, SD = 1.96, 72.8% White, 66.5% female) completed the Trier Social Stress Test (TSST), questionnaires, and clinical interviews. Stress experience (self-report), expression (observed), and physiology (salivary cortisol) were assessed during the experimental protocol. Adolescents also underwent a magnetic resonance imaging scan. RESULTS: Multitrajectory modeling revealed four profiles. High Experience-High Expression-Low Physiology (i.e., lower stress correspondence) adolescents were more likely to report depressive symptoms, lifetime nonsuicidal self-injury, and suicidal ideation relative to all other subgroups reflecting higher stress correspondence: Low Experience-Low Expression-Low Physiology, Moderate Experience-Moderate Expression-Moderate Physiology, High Experience-High Expression-High Physiology. High Experience-High Expression-Low Physiology adolescents also exhibited less positive amygdala-ventromedial prefrontal cortex resting state functional connectivity relative to Moderate Experience-Moderate Expression-Moderate Physiology. LIMITATIONS: Data were cross-sectional, precluding inference about our profiles as etiological risk factors or mechanisms of risk. CONCLUSIONS: Findings illustrate meaningful heterogeneity in adolescent stress correspondence with implications for multimodal, multilevel assessment and outcome monitoring in depression prevention and intervention efforts.
Authors: J Kaufman; B Birmaher; D Brent; U Rao; C Flynn; P Moreci; D Williamson; N Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-07 Impact factor: 8.829
Authors: Jason José Bendezú; Pamela M Cole; Patricia Z Tan; Laura Marie Armstrong; Elizabeth B Reitz; Rachel M Wolf Journal: Dev Psychopathol Date: 2017-11-16
Authors: Roberto Rentería; Corina Benjet; Raúl A Gutierrez-Garcia; Adrián Ábrego Ramírez; Yesica Albor; Guilherme Borges; María Anabell Covarrubias Díaz Couder; María Del Socorro Durán; Rogaciano González González; Rebeca Guzmán Saldaña; Alicia E Hermosillo De la Torre; Ana María Martínez-Jerez; Kalina I Martinez Martinez; María Elena Medina-Mora; Sinead Martínez Ruiz; María Abigail Paz Pérez; Gustavo Pérez Tarango; María Alicia Zavala Berbena; Enrique Méndez; Randy P Auerbach; Philippe Mortier Journal: J Affect Disord Date: 2020-11-10 Impact factor: 4.839