William Davis1, Jazmin Duque2, Q Sue Huang3, Natalie Olson1, Cameron C Grant4, E Claire Newbern3, Mark Thompson1, Ben Waite3, Namrata Prasad5, Adrian Trenholme6, Eduardo Azziz-Baumgartner7. 1. US Centers for Disease Control and Prevention, Atlanta, USA. 2. US Centers for Disease Control and Prevention, Atlanta, USA; Battelle Atlanta, Atlanta, USA; The University of Auckland, Auckland, New Zealand. 3. Institute of Environmental Science and Research, Wellington, New Zealand. 4. The University of Auckland, Auckland, New Zealand; Starship Children's Hospital, Auckland, New Zealand. 5. The University of Auckland, Auckland, New Zealand; Institute of Environmental Science and Research, Wellington, New Zealand. 6. The University of Auckland, Auckland, New Zealand; Middlemore Hospital, Auckland, New Zealand. 7. US Centers for Disease Control and Prevention, Atlanta, USA. Electronic address: lyo0@cdc.gov.
Abstract
BACKGROUND: The WHO is exploring the value of adding RSV testing to existing influenza surveillance systems to inform RSV control programs. We evaluate the usefulness of four commonly used influenza surveillance case-definitions for influenza and RSV surveillance. METHODS: SHIVERS, a multi-institutional collaboration, conducted surveillance for influenza and RSV in four New Zealand hospitals. Nurses reviewed admission logs, enrolled patients with suspected acute respiratory infections (ARI), and obtained nasopharyngeal swabs for RT-PCR. We compared the performance characteristics for identifying laboratory-confirmed influenza and RSV severe acute respiratory infection (SARI), defined as persons admitted with measured or reported fever and cough within 10 days of illness, to three other case definitions: 1. reported fever and cough or shortness of breath, 2. cough and shortness of breath, or 3. cough. RESULTS: During April-September 2012-2016, SHIVERS identified 16,055 admissions with ARI; of 6374 cases consented and tested for influenza or RSV, 5437 (85%) had SARI and 937 (15%) did not. SARI had the highest specificity in detecting influenza (40.6%) and RSV (40.8%) but the lowest sensitivity (influenza 78.8%, RSV 60.3%) among patients of all ages. Cough or shortness of breath had the highest sensitivity (influenza 99.3%, RSV 99.9%) but the lowest specificity (influenza 1.6%, RSV 1.9%). SARI sensitivity among children aged <3 months was 60.8% for influenza and 43.6% for RSV-both lower than in other age groups. CONCLUSIONS: While SARI had the highest specificity, its sensitivity was limited, especially among children aged <3 months. Cough or shortness of breath was the most sensitive.
BACKGROUND: The WHO is exploring the value of adding RSV testing to existing influenza surveillance systems to inform RSV control programs. We evaluate the usefulness of four commonly used influenza surveillance case-definitions for influenza and RSV surveillance. METHODS: SHIVERS, a multi-institutional collaboration, conducted surveillance for influenza and RSV in four New Zealand hospitals. Nurses reviewed admission logs, enrolled patients with suspected acute respiratory infections (ARI), and obtained nasopharyngeal swabs for RT-PCR. We compared the performance characteristics for identifying laboratory-confirmed influenza and RSV severe acute respiratory infection (SARI), defined as persons admitted with measured or reported fever and cough within 10 days of illness, to three other case definitions: 1. reported fever and cough or shortness of breath, 2. cough and shortness of breath, or 3. cough. RESULTS: During April-September 2012-2016, SHIVERS identified 16,055 admissions with ARI; of 6374 cases consented and tested for influenza or RSV, 5437 (85%) had SARI and 937 (15%) did not. SARI had the highest specificity in detecting influenza (40.6%) and RSV (40.8%) but the lowest sensitivity (influenza 78.8%, RSV 60.3%) among patients of all ages. Cough or shortness of breath had the highest sensitivity (influenza 99.3%, RSV 99.9%) but the lowest specificity (influenza 1.6%, RSV 1.9%). SARI sensitivity among children aged <3 months was 60.8% for influenza and 43.6% for RSV-both lower than in other age groups. CONCLUSIONS: While SARI had the highest specificity, its sensitivity was limited, especially among children aged <3 months. Cough or shortness of breath was the most sensitive.
Authors: Eduardo Azziz-Baumgartner; Lindsey M Duca; Rosalba González; Arlene Calvo; S Cornelia Kaydos-Daniels; Natalie Olson; Adam MacNeil; Vic Veguilla; Rhina Domínguez; Andrea Vicari; Rafael Rauda; Nga Vuong; Alba María Ropero; Julio Armero; Rachael Porter; Danilo Franco; Juan Miguel Pascale Journal: Lancet Reg Health Am Date: 2022-09