| Literature DB >> 34953661 |
Abstract
Recent structural studies have revealed the atomic details of how the DNA-PKcs kinase protects DNA ends, recruits and activates Artemis endonuclease for end-processing, and phosphorylates itself for end-ligation, revealing the molecular details from end-processing to end-ligation, two critical phases of the non-homologous end-joining (NHEJ) DNA-double strand break repair pathway.Entities:
Keywords: Artemis; DNA end-ligation; DNA end-processing; DNA-PK holoenzyme; non-homologous end-joining
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Year: 2021 PMID： 34953661 DOI： 10.1016/j.tcb.2021.12.002
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808