Literature DB >> 3495267

The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes measured by X-ray fluorescence.

P Csermely, S Gueth, J Somogyi.   

Abstract

Prolonged (90 minutes) incubation with tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) elicits the redistribution of zinc from the nuclear fraction and mitochondria to the cytosol and microsomes in rabbit thymocytes. The zinc redistribution might play a role in the TPA-caused desensitization of T lymphocytes towards calcium and in the TPA-induced inhibition of Gl----S phase transition and cytotoxicity of T lymphocytes.

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Year:  1987        PMID: 3495267     DOI: 10.1016/s0006-291x(87)80044-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  2 in total

1.  The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.

Authors:  Z Kiss
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857

Review 2.  Zinc Signals and Immunity.

Authors:  Martina Maywald; Inga Wessels; Lothar Rink
Journal:  Int J Mol Sci       Date:  2017-10-24       Impact factor: 5.923

  2 in total

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