Literature DB >> 3495222

Rearrangement of chromosome 21 in Alzheimer's disease.

J M Delabar, Y Lamour, A Gegonne, P Davous, M Roudier, A Nicole, I Ceballos, P Amouyel, D Stehelin, P M Sinet.   

Abstract

We have analyzed the DNA from four patients suffering from a dementia of the Alzheimer type and of four controls of identical age. Estimates of the copy numbers of two genes located on chromosome 21, SOD1 and ETS2, gave the following results: in all the cases there was duplication of ETS2 whereas SOD1 was normal. These preliminary results indicate that the segment of chromosome 21(q21----q22.1) is rearranged in all the four patients who were investigated.

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Year:  1986        PMID： 3495222

Source DB:  PubMed          Journal:  Ann Genet        ISSN： 0003-3995


  4 in total

1.  Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

Authors:  Z Rahmani; J L Blouin; N Creau-Goldberg; P C Watkins; J F Mattei; M Poissonnier; M Prieur; Z Chettouh; A Nicole; A Aurias
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

2.  Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease.

Authors:  N Sacchi; J Nalbantoglu; F R Sergovich; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

3.  Submicroscopic duplication of chromosome 21 and trisomy 21 phenotype (Down syndrome).

Authors:  J M Delabar; P M Sinet; B Chadefaux; A Nicole; A Gegonne; D Stehelin; F Fridlansky; N Créau-Goldberg; C Turleau; J de Grouchy
Journal:  Hum Genet       Date:  1987-07       Impact factor: 4.132

4.  Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene.

Authors:  G J Mavrothalassitis; D K Watson; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205
  4 in total

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