Literature DB >> 34950410

Clinical Problem Solving: An Older Woman With Weakness from Head to Toe.

David A Hartmann1, Meredith Bock2, Vanja Douglas2, Josiah Gerdts2, Biswarathan Ramani3, Maulik Shah2.   

Abstract

A 67-year-old woman was admitted to our hospital for progressive weakness, dysphagia, muscle pain, and weight loss. Here we detail the clinical problem solving involved in diagnosing and treating her immune-mediated necrotizing myopathy caused by anti-HMGCoA reductase autoantibodies. Interestingly, this diagnosis coincided with discovery of a gastrointestinal stromal tumor (GIST) and positivity for anti-nuclear matrix protein (anti-NXP2), another myositis specific autoantibody.
© The Author(s) 2021.

Entities:  

Keywords:  autoimmune diseases of the nervous system; clinical specialty; education; muscular diseases; myositis; neuromuscular disease; neuromuscular diseases; techniques

Year:  2021        PMID： 34950410      PMCID： PMC8689558          DOI： 10.1177/19418744211005321

Source DB:  PubMed          Journal:  Neurohospitalist        ISSN： 1941-8744


  16 in total

1.  More severe disease and slower recovery in younger patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy.

Authors:  Eleni Tiniakou; Iago Pinal-Fernandez; Thomas E Lloyd; Jemima Albayda; Julie Paik; Jessie L Werner; Cassie A Parks; Livia Casciola-Rosen; Lisa Christopher-Stine; Andrew L Mammen
Journal:  Rheumatology (Oxford)       Date:  2017-05-01       Impact factor: 7.580

2.  224th ENMC International Workshop:: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14-16 October 2016.

Authors:  Yves Allenbach; Andrew L Mammen; Olivier Benveniste; Werner Stenzel
Journal:  Neuromuscul Disord       Date:  2017-10-23       Impact factor: 4.296

3.  Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.

Authors:  Andrew L Mammen; Tae Chung; Lisa Christopher-Stine; Paul Rosen; Antony Rosen; Kimberly R Doering; Livia A Casciola-Rosen
Journal:  Arthritis Rheum       Date:  2011-03

4.  Differential Clinical Associations of Anti-Nuclear Matrix Protein 2 Autoantibodies in Patients With Idiopathic Inflammatory Myopathies.

Authors:  Hanbo Yang; Xin Lu; Qinglin Peng; Wei Jiang; Jingli Shi; Yamei Zhang; He Chen; Guochun Wang
Journal:  Arthritis Rheumatol       Date:  2018-06-27       Impact factor: 10.995

5.  A case of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody-positive paraneoplastic necrotizing myopathy associated with advanced gastric cancer that responded to intravenous immunoglobulin therapy.

Authors:  Tomohisa Yamaguchi; Akiko Matsunaga; Masamichi Ikawa; Norimichi Shirafuji; Ichizo Nishino; Tadanori Hamano
Journal:  Rinsho Shinkeigaku       Date:  2017-02-22

6.  Clinical Features and Treatment Outcomes of Necrotizing Autoimmune Myopathy.

Authors:  Charles D Kassardjian; Vanda A Lennon; Nora B Alfugham; Michael Mahler; Margherita Milone
Journal:  JAMA Neurol       Date:  2015-09       Impact factor: 18.302

7.  Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies.

Authors:  Kubéraka Mariampillai; Benjamin Granger; Damien Amelin; Marguerite Guiguet; Eric Hachulla; François Maurier; Alain Meyer; Aline Tohmé; Jean-Luc Charuel; Lucile Musset; Yves Allenbach; Olivier Benveniste
Journal:  JAMA Neurol       Date:  2018-12-01       Impact factor: 18.302

8.  The reliability of immunoassays to detect autoantibodies in patients with myositis is dependent on autoantibody specificity.

Authors:  Sarah L Tansley; Danyang Li; Zoe E Betteridge; Neil J McHugh
Journal:  Rheumatology (Oxford)       Date:  2020-08-01       Impact factor: 7.580

9.  Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients.

Authors:  Alain Meyer; Yves Troyanov; Julie Drouin; Geneviève Oligny-Longpré; Océane Landon-Cardinal; Sabrina Hoa; Baptiste Hervier; Josiane Bourré-Tessier; Anne-Marie Mansour; Sara Hussein; Vincent Morin; Eric Rich; Jean-Richard Goulet; Sandra Chartrand; Marie Hudson; Jessica Nehme; Jean-Paul Makhzoum; Farah Zarka; Edith Villeneuve; Jean-Pierre Raynauld; Marianne Landry; Erin K O'Ferrall; Jose Ferreira; Benjamin Ellezam; Jason Karamchandani; Sandrine Larue; Rami Massie; Catherine Isabelle; Isabelle Deschênes; Valérie Leclair; Hélène Couture; Ira N Targoff; Marvin J Fritzler; Jean-Luc Senécal
Journal:  Arthritis Res Ther       Date:  2020-01-08       Impact factor: 5.156

Review 10.  Anti-HMGCR Myopathy.

Authors:  Payam Mohassel; Andrew L Mammen
Journal:  J Neuromuscul Dis       Date:  2018
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