Literature DB >> 3494809

Aging in man. Linear increase of a novel T cell subset defined by antiganglioside monoclonal antibody 3G5.

S L Rabinowe, R C Nayak, K Krisch, K L George, G S Eisenbarth.   

Abstract

A new human T cell subset defined by antineuronal ganglioside mAb 3G5 increases linearly with advancing age in man. The percentage of circulating 3G5+ T cells in 21 normal individuals, quantitated by cytofluorograph analysis, increases linearly from age 7 (23-30%) to age 84 (58%) (r = 0.85, p less than 0.001). The antigen on T cells has the biochemical properties of a ganglioside that migrates between GM1 and GM2 ganglioside markers on TLC. The 3G5 subset represents the first T cell subset that reflects aging in man.

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Year:  1987        PMID： 3494809      PMCID： PMC2188319          DOI： 10.1084/jem.165.5.1436

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  An enzyme-linked immunosorbent assay (ELISA) for the detection of monoclonal antibodies to cell surface antigens on viable cells.

Authors:  M R Posner; D Antoniou; J Griffin; S F Schlossman; H Lazarus
Journal:  J Immunol Methods       Date:  1982       Impact factor: 2.303

Review 2.  The differentiation and function of human T lymphocytes.

Authors:  E L Reinherz; S F Schlossman
Journal:  Cell       Date:  1980-04       Impact factor: 41.582

3.  Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease.

Authors:  W A Valente; P Vitti; Z Yavin; E Yavin; C M Rotella; E F Grollman; R S Toccafondi; L D Kohn
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

4.  A procedure for the quantitative isolation of brain gangliosides.

Authors:  L Svennerholm; P Fredman
Journal:  Biochim Biophys Acta       Date:  1980-01-18

5.  Amiodarone therapy and autoimmune thyroid disease. Increase in a new monoclonal antibody-defined T cell subset.

Authors:  S L Rabinowe; P R Larsen; E M Antman; K L George; P L Friedman; R A Jackson; G S Eisenbarth
Journal:  Am J Med       Date:  1986-07       Impact factor: 4.965

Review 6.  Biosynthesis and function of gangliosides.

Authors:  P H Fishman; R O Brady
Journal:  Science       Date:  1976-11-26       Impact factor: 47.728

7.  Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.

Authors:  B F Haynes; K Shimizu; G S Eisenbarth
Journal:  J Clin Invest       Date:  1983-01       Impact factor: 14.808

8.  Specific gangliosides function as host cell receptors for Sendai virus.

Authors:  M A Markwell; L Svennerholm; J C Paulson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells.

Authors:  G S Eisenbarth; K Shimizu; M A Bowring; S Wells
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

10.  Monoclonal antibody to ganglioside GQ discriminates between haemopoietic cells and infiltrating neuroblastoma tumour cells in bone marrow.

Authors:  J T Kemshead; F Walsh; J Pritchard; M Greaves
Journal:  Int J Cancer       Date:  1981       Impact factor: 7.396
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  2 in total

1.  Cultured Human Adipose Tissue Pericytes and Mesenchymal Stromal Cells Display a Very Similar Gene Expression Profile.

Authors:  Lindolfo da Silva Meirelles; Tathiane Maistro Malta; Virgínia Mara de Deus Wagatsuma; Patrícia Viana Bonini Palma; Amélia Goes Araújo; Kelen Cristina Ribeiro Malmegrim; Fábio Morato de Oliveira; Rodrigo Alexandre Panepucci; Wilson Araújo Silva; Simone Kashima Haddad; Dimas Tadeu Covas
Journal:  Stem Cells Dev       Date:  2015-08-19       Impact factor: 3.272

2.  A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes.

Authors:  R C Nayak; A B Berman; K L George; G S Eisenbarth; G L King
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307
  2 in total

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