Literature DB >> 3494784

An enzyme-linked immunosorbent assay for the detection and quantitation of anti-Jo-1 antibody in human serum.

T Biswas, F W Miller, Y Takagaki, P H Plotz.   

Abstract

We have developed an enzyme-linked immunosorbent assay (ELISA) specific for autoantibodies directed against the autoantigen Jo-1 (histidyl-tRNA synthetase) using antigen prepared biochemically from HeLa cells. No other patient sera, including those containing antibodies directed at threonyl-tRNA synthetase or alanyl-tRNA synthetase, reacted in the assay. Screening of sera from 169 patients with a variety of autoimmune and neuromuscular diseases confirmed that anti-Jo-1 antibodies are confined to a subgroup of patients with pure polymyositis, pure dermatomyositis, or myositis associated with another rheumatic disease.

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Year:  1987        PMID： 3494784     DOI： 10.1016/0022-1759(87)90011-1

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  5 in total

1.  Detection of anti-PL-12 autoantibodies by ELISA using a recombinant antigen; study of the immunoreactive region.

Authors:  J R García-Lozano; M F González-Escribano; R Rodríguez; J L Rodriguez-Sanchez; I N Targoff; I Wichmann; A Núñez-Roldán
Journal:  Clin Exp Immunol       Date:  1998-11       Impact factor: 4.330

2.  Origin and regulation of a disease-specific autoantibody response. Antigenic epitopes, spectrotype stability, and isotype restriction of anti-Jo-1 autoantibodies.

Authors:  F W Miller; S A Twitty; T Biswas; P H Plotz
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

3.  Lymphocyte activation markers in idiopathic myositis: changes with disease activity and differences among clinical and autoantibody subgroups.

Authors:  F W Miller; L A Love; S A Barbieri; J E Balow; P H Plotz
Journal:  Clin Exp Immunol       Date:  1990-09       Impact factor: 4.330

4.  Anti-KJ: a new antibody associated with the syndrome of polymyositis and interstitial lung disease.

Authors:  I N Targoff; F C Arnett; L Berman; C O'Brien; M Reichlin
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

Review 5.  Laboratory evaluation of the inflammatory myopathies.

Authors:  L G Rider; F W Miller
Journal:  Clin Diagn Lab Immunol       Date:  1995-01
  5 in total

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