Literature DB >> 3494774

Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line.

L B Lachman, D C Brown, C A Dinarello.   

Abstract

IL 1 can exhibit dichotomous effects in the sense that it is cytotoxic for certain cells, although growth promoting for other cells. Because IL 1 is growth promoting for astrocytes, but cytotoxic for melanoma cells, the current investigation evaluated the effect of IL 1 upon astrocytomas. The human astrocytoma U373 was found to incorporate [3H]thymidine after exposure to recombinant human IL 1 alpha and IL 1 beta and murine IL 1 alpha. Surprisingly, U373 also incorporated [3H]thymidine after exposure to recombinant TNF. The response of the U373 to IL 1 may be used as a simple and sensitive assay for IL 1.

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Year:  1987        PMID： 3494774

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  25 in total

1.  Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

Authors:  K Selmaj; C S Raine; B Cannella; C F Brosnan
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

2.  Distribution of endogenous tumour necrosis factor alpha in gliomas.

Authors:  M Maruno; J S Kovach; P J Kelly; T Yanagihara
Journal:  J Clin Pathol       Date:  1997-07       Impact factor: 3.411

3.  Soluble factors, including TNF alpha, secreted by human T cells are both cytotoxic and cytostatic for medulloblastoma cells.

Authors:  N Dufay; A Reboul; F Touraine-Moulin; M F Belin; P Giraudon
Journal:  J Neurooncol       Date:  1999-06       Impact factor: 4.130

4.  Modulation of interleukin-1 and tumor necrosis factor expression by beta-adrenergic agonists in mouse ameboid microglial cells.

Authors:  E Hetier; J Ayala; A Bousseau; A Prochiantz
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

5.  Species-specific TNF induction of thymocyte proliferation.

Authors:  M J Ehrke; R L Ho; K Hori
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

6.  Functional and morphological effects of tumour necrosis factor alpha in an interleukin 6-producing pulmonary large cell carcinoma with sarcomatoid features.

Authors:  T Motoyama; H Watanabe; T Kumanishi; H Usui; H Hashimoto; T Hachisu; I Fukamachi; T Arai; K Takehara
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

7.  IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

Authors:  T Kasahara; N Mukaida; K Yamashita; H Yagisawa; T Akahoshi; K Matsushima
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

8.  Differences in the interactions of Nocardia asteroides with macrophage, endothelial, and astrocytoma cell lines.

Authors:  L Beaman; B L Beaman
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

9.  Responses of human glioblastoma cells to human natural tumor necrosis factor-alpha: susceptibility, mechanism of resistance and cytokine production studies.

Authors:  S Sakuma; Y Sawamura; M Tada; T Aida; H Abe; K Suzuki; N Taniguchi
Journal:  J Neurooncol       Date:  1993-03       Impact factor: 4.130

10.  Modulation of cisplatin sensitivity and growth rate of an ovarian carcinoma cell line by bombesin and tumor necrosis factor-alpha.

Authors:  S Isonishi; A P Jekunen; D K Hom; A Eastman; P S Edelstein; F B Thiebaut; R D Christen; S B Howell
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808
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