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Literature DB >> 3494246

Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro.

Abstract

The key biochemical process of the vertebrate visual cycle required for rhodopsin regeneration, 11-cis-retinoid production from all-trans-retinoids, is shown to occur in vitro. A 600 X g supernatant from a frog retina/pigment epithelium homogenate transforms added all-trans-[3H]retinol, in a time-dependent fashion, to a mixture of 11-cis-retinol, 11-cis-retinal, and 11-cis-retinyl palmitate. 13-cis-Retinoids are formed in only minor amounts by nonspecific processes. Studies using washed particulate fractions of the 600 X g supernatant indicate that all-trans-[3H]retinol is isomerized to 11-cis-retinoids much more effectively than is all-trans-[3H]retinal or all-trans-[3H]retinyl palmitate. The 11-cis-retinoid biosynthetic activity is heat-labile, sedimentable by high-speed centrifugation, and largely found in the pigment epithelium rather than in the neural retina.

Entities: Chemical Gene Mutation

Mesh：

Substances：

Year: 1987 PMID： 3494246 PMCID： PMC304538 DOI： 10.1073/pnas.84.7.1849

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Biochemical aspects of the visual process. XIX. Formation of isorhodopsin from photolyzed rhodopsin by bacterial action.

Authors: J P Rotmans; F J Daemen; S L Bonting
Journal: Biochim Biophys Acta Date: 1972-06-23

2. Site of attachment of retinal in rhodopsin.

Authors: D Bownds
Journal: Nature Date: 1967-12-23 Impact factor: 49.962

3. Studies on a missing reaction in the visual cycle.

Authors: S Amer; M Akhtar
Journal: Nat New Biol Date: 1972-06-28

4. 9-Cis isomerization of all-trans retinal during in vitro regeneration of visual pigment.

Authors: I A Ostapenko; V V Furayev
Journal: Nat New Biol Date: 1973-06-06

5. Cis-trans isomers of vitamin A and retinene in the rhodopsin system.

Authors: R HUBBARD; G WALD
Journal: J Gen Physiol Date: 1952-11 Impact factor: 4.086

6. Nonstereospecific biosynthesis of 11-cis-retinal in the eye.

Authors: P S Bernstein; J R Lichtman; R R Rando
Journal: Biochemistry Date: 1985-01-15 Impact factor: 3.162

7. Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids.

Authors: C D Bridges; R A Alvarez; S L Fong; F Gonzalez-Fernandez; D M Lam; G I Liou
Journal: Vision Res Date: 1984 Impact factor: 1.886

8. The specific inhibition of 11-cis-retinyl palmitate formation in the frog eye by diaminophenoxypentane, an inhibitor of rhodopsin regeneration.

Authors: P S Bernstein; R R Rando
Journal: Vision Res Date: 1985 Impact factor: 1.886

9. In vivo isomerization of all-trans- to 11-cis-retinoids in the eye occurs at the alcohol oxidation state.

Authors: P S Bernstein; R R Rando
Journal: Biochemistry Date: 1986-10-21 Impact factor: 3.162

10. Retinene isomerase.

Authors: R HUBBARD
Journal: J Gen Physiol Date: 1956-07-20 Impact factor: 4.086

39 in total

Review 1. The many different cellular functions of MYO7A in the retina.

Authors: David S Williams; Vanda S Lopes
Journal: Biochem Soc Trans Date: 2011-10 Impact factor: 5.407

Review 2. The retinal pigment epithelium in health and disease.

Authors: J R Sparrow; D Hicks; C P Hamel
Journal: Curr Mol Med Date: 2010-12 Impact factor: 2.222

3. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.

Authors: Olga Nikolaeva; Yusuke Takahashi; Gennadiy Moiseyev; Jian-Xing Ma
Journal: FEBS J Date: 2009-04-20 Impact factor: 5.542

4. Importance of membrane structural integrity for RPE65 retinoid isomerization activity.

Authors: Marcin Golczak; Philip D Kiser; David T Lodowski; Akiko Maeda; Krzysztof Palczewski
Journal: J Biol Chem Date: 2010-01-25 Impact factor: 5.157

5. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters.

Authors: C A Driessen; H J Winkens; K Hoffmann; L D Kuhlmann; B P Janssen; A H Van Vugt; J P Van Hooser; B E Wieringa; A F Deutman; K Palczewski; K Ruether; J J Janssen
Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

6. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species.

Authors: Yusuke Takahashi; Gennadiy Moiseyev; Ying Chen; Olga Nikolaeva; Jian-Xing Ma
Journal: FEBS J Date: 2011-07-01 Impact factor: 5.542

7. Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.

Authors: J Wang; X Chai; U Eriksson; J L Napoli
Journal: Biochem J Date: 1999-02-15 Impact factor: 3.857