Animal experiments on the role of T lymphocytes in the course of antineoplastic chemotherapy. I. Chemotherapy and tumor-specific immunity.

Strain 2 guinea pigs bearing an intradermally growing already lymphogenetically metastasized line 10 tumor received intralesional chemotherapy with either cisplatin or vincristine. After successful treatment with cisplatin and low-dose vincristine, nearly all animals developed tumor-specific immunity. This phenomenon was not observed in animals treated with high-dose vincristine. Possible mechanisms of generation and alteration of primary T-cell-induced posttherapeutic tumor immunity are discussed.