Literature DB >> 3494208

Older dopaminergic neurons do not recover from the effects of MPTP.

G A Ricaurte, L E DeLanney, I Irwin, J W Langston.   

Abstract

Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to assess whether or not older dopaminergic neurons were capable of similar recovery. We now report that older dopaminergic neurons do not recover from the effects of MPTP. This suggests that with age, neurons in the nigrostriatal system begin to lose their regenerative capacity. This phenomenon could underlie the process of neuronal degeneration known to occur in a number of age-related diseases, including Parkinson's disease.

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Year:  1987        PMID： 3494208     DOI： 10.1016/0028-3908(87)90051-7

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  5 in total

1.  Effects of age, gender, and gonadectomy on neurochemistry and behavior in animal models of Parkinson's disease.

Authors:  Andrea Tamás; Andrea Lubics; István Lengvári; Dóra Reglodi
Journal:  Endocrine       Date:  2006-04       Impact factor: 3.633

2.  Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.

Authors:  Paola Sgadò; Lavinia Albéri; Daniel Gherbassi; Sherri L Galasso; Geert M J Ramakers; Kambiz N Alavian; Marten P Smidt; Richard H Dyck; Horst H Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-02       Impact factor: 11.205

Review 3.  Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?

Authors:  Christopher A Shaw; Günter U Höglinger
Journal:  Neuromolecular Med       Date:  2007-11-06       Impact factor: 3.843

4.  Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease.

Authors:  A Ho; M Blum
Journal:  J Neurosci       Date:  1998-08-01       Impact factor: 6.167

5.  Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation.

Authors:  Francesca L'Episcopo; Cataldo Tirolo; Nunzio Testa; Salvatore Caniglia; Maria C Morale; Francesco Impagnatiello; Stefano Pluchino; Bianca Marchetti
Journal:  J Neurosci       Date:  2013-01-23       Impact factor: 6.167
  5 in total

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