Literature DB >> 3493775

Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells--evidence for complex breakdown of inositol(1,3,4)trisphosphate.

R F Irvine, A J Letcher, D J Lander, J P Heslop, M J Berridge.   

Abstract

Analysis of inositol bisphosphates in GH4 cells labelled with [3H]myo-inositol shows that these cells contain three detectable inositol bisphosphates: inositol(1,4)bisphosphate, and two novel inositol bisphosphates. These latter inositol bisphosphates were degraded by periodate oxidation, borohydride reduction and alkaline phosphatase dephosphorylation; each yielded single non-cyclic alditols, ribitol and threitol, indicating that they must be respectively inositol(1,3)bisphosphate and inositol(3,4) bisphosphate. These two inositol bisphosphates are putative breakdown products of inositol(1,3,4)trisphosphate, and their occurrence suggests a complex route of hydrolysis of inositol(1,3,4)trisphosphate in intact cells.

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Year:  1987        PMID： 3493775     DOI： 10.1016/0006-291x(87)90672-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

Authors:  S B Shears; J B Parry; E K Tang; R F Irvine; R H Michell; C J Kirk
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

2.  Numbering of atoms in myo-inositol. Recommendations 1988. Nomenclature Committee of the International Union of Biochemistry.

Authors: 
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

3.  Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues.

Authors:  R F Irvine; A J Letcher; D J Lander; B K Drøbak; A P Dawson; A Musgrave
Journal:  Plant Physiol       Date:  1989-03       Impact factor: 8.340

4.  1D-myo-inositol 1,4,5-trisphosphate dephosphorylation by rat enterocytes involves an intracellular 5-phosphatase and non-specific phosphatase activity at the cell surface.

Authors:  C Rubiera; G Velasco; R H Michell; P S Lazo; S B Shears
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

5.  The inositol phosphates in WRK1 rat mammary tumour cells.

Authors:  N S Wong; C J Barker; A J Morris; A Craxton; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

6.  Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells.

Authors:  N S Wong; C J Barker; S B Shears; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

7.  Accumulation of inositol polyphosphate isomers in agonist-stimulated cerebral-cortex slices. Comparison with metabolic profiles in cell-free preparations.

Authors:  I H Batty; A J Letcher; S R Nahorski
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

8.  The pathway of myo-inositol 1,3,4-trisphosphate dephosphorylation in liver.

Authors:  S B Shears; C J Kirk; R H Michell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

9.  Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells.

Authors:  N M Dean; J D Moyer
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

10.  Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos.

Authors:  R F Irvine; A J Letcher; L R Stephens; A Musgrave
Journal:  Biochem J       Date:  1992-01-01       Impact factor: 3.857
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