| Literature DB >> 34936882 |
Xin Sun1, Anne-Karina Perl2, Rongbo Li3, Sheila M Bell4, Eniko Sajti3, Vladimir V Kalinichenko5, Tanya V Kalin2, Ravi S Misra6, Hitesh Deshmukh2, Geremy Clair7, Jennifer Kyle7, Laura E Crotty Alexander8, Jorge A Masso-Silva8, Joseph A Kitzmiller4, Kathryn A Wikenheiser-Brokamp9, Gail Deutsch10, Minzhe Guo2, Yina Du4, Michael P Morley11, Michael J Valdez3, Haoze V Yu3, Kang Jin12, Eric E Bardes12, Jarod A Zepp13, Terren Neithamer11, Maria C Basil11, William J Zacharias14, Jamie Verheyden3, Randee Young3, Gautam Bandyopadhyay6, Sara Lin15, Charles Ansong7, Joshua Adkins7, Nathan Salomonis16, Bruce J Aronow12, Yan Xu2, Gloria Pryhuber6, Jeff Whitsett2, Edward E Morrisey17.
Abstract
The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing and genetic lineage tracing have revealed novel cell types and enriched functional properties of existing cell types in lung. The time has come to take a new census. Initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community, we synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication will serve as the starting point of a live, up-to-date guide for lung research at https://www.lungmap.net/cell-cards/. We hope that Lung CellCards will promote the community-wide effort to establish, maintain, and restore respiratory health.Entities:
Keywords: COVID; CellCards; LungMAP; cell cards; disease; lung; regeneration; repair; resource; single cell
Mesh：
Year: 2021 PMID： 34936882 PMCID： PMC9202574 DOI： 10.1016/j.devcel.2021.11.007
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 13.417