Literature DB >> 3493160

Tracheal epithelium releases a vascular smooth muscle relaxant factor: demonstration by bioassay.

M Ilhan, I Sahin.   

Abstract

Acetylcholine caused no relaxation of a rubbed strip from rabbit aorta (RASR) which was precontracted with phenylephrine. When the same strip was taken into epithelium-intact guinea-pig trachea, acetylcholine produced a slow-developing relaxation which was antagonized by atropine but not by propranolol, indomethacin, theophylline or hydroquinone. RASR was not relaxed by acetylcholine when it was taken from epithelium-rubbed trachea. The results indicate that acetylcholine releases vascular smooth muscle relaxant factor from tracheal epithelium.

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Year:  1986        PMID： 3493160     DOI： 10.1016/0014-2999(86)90586-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Role of epithelium in agonist-induced contractile responses of guinea-pig trachealis: influence of the surface through which drug enters the tissue.

Authors:  C F Iriarte; R Pascual; M M Villanueva; M Román; J Cortijo; E J Morcillo
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

Review 2.  Epithelium derived relaxing factor: myth or reality?

Authors:  P M Vanhoutte
Journal:  Thorax       Date:  1988-09       Impact factor: 9.139

3.  Co-axial bioassay of a smooth muscle relaxant factor released from guinea-pig tracheal epithelium.

Authors:  L B Fernandes; J W Paterson; R G Goldie
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

4.  Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin-induced contractions of guinea-pig isolated trachea.

Authors:  P Devillier; C Advenier; G Drapeau; J Marsac; D Regoli
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

5.  The effects of alterations in electrogenic Na+/K+ -pumping in guinea-pig isolated trachealis: their modulation by the epithelium.

Authors:  D Raeburn; J S Fedan
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

6.  Pharmacological evaluation of a guinea-pig tracheal epithelium-derived inhibitory factor (EpDIF).

Authors:  L B Fernandes; R G Goldie
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

7.  Bronchodilatation of guinea-pig perfused bronchioles induced by the H3-receptor for histamine: role of epithelium.

Authors:  J L Burgaud; N Oudart
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

8.  Characterization of muscarinic receptors that mediate contraction of guinea-pig isolated trachea to choline esters: effect of removing epithelium.

Authors:  K J Morrison; P M Vanhoutte
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

9.  Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor.

Authors:  Ross Vlahos; Maurice E Fabiani; David F Story
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-09-18       Impact factor: 3.000

10.  Airway epithelial cells regulate membrane potential, neurotransmission and muscle tone of the dog airway smooth muscle.

Authors:  Z Xie; H Hakoda; Y Ito
Journal:  J Physiol       Date:  1992-04       Impact factor: 5.182
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