Literature DB >> 34930023

Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin.

Q C Truong-Bolduc1, Y Wang1, J L Reedy1, J M Vyas1, D C Hooper1.   

Abstract

Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact norA and mepA, respectively.

Entities:  

Keywords:  MepA; NorA; Staphylococcus aureus; chlorhexidine; ciprofloxacin; mupirocin

Mesh：

Substances：

Year:  2021        PMID： 34930023      PMCID： PMC8846467          DOI： 10.1128/AAC.01845-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  23 in total

1.  Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.

Authors:  Carmen E DeMarco; Laurel A Cushing; Emmanuel Frempong-Manso; Susan M Seo; Tinevimbo A A Jaravaza; Glenn W Kaatz
Journal:  Antimicrob Agents Chemother       Date:  2007-06-18       Impact factor: 5.191

2.  Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus.

Authors:  R Novick
Journal:  Virology       Date:  1967-09       Impact factor: 3.616

3.  Frequency of efflux pump genes mediating ciprofloxacin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates.

Authors:  Sepideh Hassanzadeh; Rahil Mashhadi; Masoud Yousefi; Emran Askari; Maryam Saniei; Mohammad Reza Pourmand
Journal:  Microb Pathog       Date:  2017-08-18       Impact factor: 3.738

4.  Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors:  H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

5.  Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial.

Authors:  Susan S Huang; Edward Septimus; Ken Kleinman; Julia Moody; Jason Hickok; Lauren Heim; Adrijana Gombosev; Taliser R Avery; Katherine Haffenreffer; Lauren Shimelman; Mary K Hayden; Robert A Weinstein; Caren Spencer-Smith; Rebecca E Kaganov; Michael V Murphy; Tyler Forehand; Julie Lankiewicz; Micaela H Coady; Lena Portillo; Jalpa Sarup-Patel; John A Jernigan; Jonathan B Perlin; Richard Platt
Journal:  Lancet       Date:  2019-03-05       Impact factor: 79.321

6.  Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein.

Authors:  Glenn W Kaatz; Fionnuala McAleese; Susan M Seo
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

7.  Comparative genomics of Staphylococcus aureus musculoskeletal isolates.

Authors:  James E Cassat; Paul M Dunman; Fionnuala McAleese; Ellen Murphy; Steven J Projan; Mark S Smeltzer
Journal:  J Bacteriol       Date:  2005-01       Impact factor: 3.490

8.  Tet38 Efflux Pump Affects Staphylococcus aureus Internalization by Epithelial Cells through Interaction with CD36 and Contributes to Bacterial Escape from Acidic and Nonacidic Phagolysosomes.

Authors:  Q C Truong-Bolduc; N S Khan; J M Vyas; D C Hooper
Journal:  Infect Immun       Date:  2017-01-26       Impact factor: 3.441

9.  Comparative activity of ozenoxacin and other quinolones in Staphylococcus aureus strains overexpressing the efflux pump-encoding genes mepA and norA.

Authors:  Y López; M Tato; D Gargallo-Viola; R Cantón; J Vila; I Zsolt
Journal:  Int J Antimicrob Agents       Date:  2020-07-10       Impact factor: 5.283

10.  Mupirocin Resistance Among Methicillin Resistant Staphylococcus Isolates in a Tertiary Health Care Center.

Authors:  Seema Mittal; Pallavi Sayal; Priyanka Yadav; Ashok Kumar; Manisha Rajian
Journal:  Infect Disord Drug Targets       Date:  2019
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  1 in total

Review 1.  Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.

Authors:  Ronit Vogt Sionov; Doron Steinberg
Journal:  Microorganisms       Date:  2022-06-16
  1 in total

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