Fabrizio Minervini1, Laura Boschetti2, Michael Gregor2, Mariano Provencio3, Virginia Calvo3, Peter B Kestenholz1, Savvas Lampridis4, Davide Patrini5, Pietro Bertoglio6, L Filipe Azenha1, Consolato M Sergi7, Gregor J Kocher8. 1. Department of Thoracic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland. 2. Department of Hematology, Cantonal Hospital Lucerne, Lucerne, Switzerland. 3. Department of Medical Oncology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain. 4. Department of Thoracic Surgery, 424 General Military Hospital, Thessaloniki, Greece. 5. Department of Thoracic Surgery, University College London Hospitals, London, UK. 6. Division of Thoracic Surgery, IRCSS Azienda Ospedaliero-Universitaria, Bologna, Italy. 7. Division of Anatomic Pathology, Children's Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada. 8. Division of Thoracic Surgery, Bern University Hospital, University of Bern, Bern, Switzerland.
Abstract
OBJECTIVE: This study aimed to provide an extensive overview of clinical and pathological findings along with various therapeutic options analyzing in addiction, retrospectively, the surgical outcomes of a single center cohort. BACKGROUND: Thymic neoplasms are rare thoracic tumors which commonly are located in the anterior mediastinum and are associated with a wide spectrum of clinical presentations. They may run an indolent course or could present a very aggressive biologic progression with infiltration of mediastinal structures and presence of distant metastases. The pathogenesis of these tumors is so far not completely clear. Several treatment modalities in a multidisciplinary setting have to be considered in order to provide the best treatment for patients affected by thymic tumors. METHODS: We conducted a retrospective cohort analysis of all patients who underwent surgery due to thymic tumor in a university hospital located in Switzerland (Bern University Hospital) and then we performed a narrative review of the English literature using PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus. CONCLUSIONS: Minimally invasive techniques play an important role in the treatment of thymic tumors. A careful patients selection in a multidisciplinary setting is mandatory in order to offer the best treatment for patients affected by thymic tumors. 2021 Gland Surgery. All rights reserved.
OBJECTIVE: This study aimed to provide an extensive overview of clinical and pathological findings along with various therapeutic options analyzing in addiction, retrospectively, the surgical outcomes of a single center cohort. BACKGROUND: Thymic neoplasms are rare thoracic tumors which commonly are located in the anterior mediastinum and are associated with a wide spectrum of clinical presentations. They may run an indolent course or could present a very aggressive biologic progression with infiltration of mediastinal structures and presence of distant metastases. The pathogenesis of these tumors is so far not completely clear. Several treatment modalities in a multidisciplinary setting have to be considered in order to provide the best treatment for patients affected by thymic tumors. METHODS: We conducted a retrospective cohort analysis of all patients who underwent surgery due to thymic tumor in a university hospital located in Switzerland (Bern University Hospital) and then we performed a narrative review of the English literature using PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus. CONCLUSIONS: Minimally invasive techniques play an important role in the treatment of thymic tumors. A careful patients selection in a multidisciplinary setting is mandatory in order to offer the best treatment for patients affected by thymic tumors. 2021 Gland Surgery. All rights reserved.
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