Literature DB >> 3492412

Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats.

P S Olsen, S S Poulsen, K Therkelsen, E Nexø.   

Abstract

The effect of extirpation of the submandibular glands, an exocrine organ for epidermal growth factor/urogastrone (EGF/URO), and the effect of oral administration of synthetic human (EGF/URO) on healing of chronic gastric ulcers in rats has been investigated. Removal of the submandibular glands delayed healing of chronic gastric ulcers when examined after 50, 100, and 200 days. Oral administration of synthetic human EGF/URO stimulated gastric ulcer healing when examined after 25 and 50 days of treatment. The effect of synthetic human EGF/URO was comparable with that of cimetidine. The combined administration of synthetic human EGF/URO and cimetidine further increased healing of gastric ulcers compared with administration of each substance. Neither synthetic human EGF/URO, nor removal of the submandibular glands had any influence on gastric acid secretion. This study showed that the submandibular glands influence healing of chronic gastric ulcers and suggest that EGF/URO participate in healing of chronic gastric ulcers in rats.

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Year:  1986        PMID： 3492412      PMCID： PMC1433984          DOI： 10.1136/gut.27.12.1443

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  26 in total

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Authors:  R D Rosin; G Exarchakos; H Ellis
Journal:  Surgery       Date:  1976-05       Impact factor: 3.982

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Journal:  Science       Date:  1977-08-19       Impact factor: 47.728

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Authors:  G Carpenter; S Cohen
Journal:  J Cell Physiol       Date:  1976-06       Impact factor: 6.384

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Authors:  J B Elder; G Williams; E Lacey; H Gregory
Journal:  Nature       Date:  1978-02-02       Impact factor: 49.962

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Journal:  Experientia       Date:  1971-02-15

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Journal:  Dev Biol       Date:  1979-08       Impact factor: 3.582

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Authors:  K J Lembach
Journal:  J Cell Physiol       Date:  1976-10       Impact factor: 6.384

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Journal:  Am J Physiol       Date:  1980-01

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Authors:  R A Murphy; J D Saide; M H Blanchard; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

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Authors:  K A Skinner; B L Tepperman
Journal:  Gastroenterology       Date:  1981-08       Impact factor: 22.682
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  24 in total

Review 1.  Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy?

Authors:  W M Wong; R J Playford; N A Wright
Journal:  Gut       Date:  2000-02       Impact factor: 23.059

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Authors:  P D Jones; N Hudson; C J Hawkey
Journal:  BMJ       Date:  1992-02-22

3.  Submandibular salivary glands: influence on growth rate and life span in mice.

Authors:  Ignasi Ramírez; Maria Soley
Journal:  J Physiol Biochem       Date:  2010-12-31       Impact factor: 4.158

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Authors:  R J Playford; N A Wright
Journal:  Gut       Date:  1996-03       Impact factor: 23.059

6.  Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats.

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Journal:  Gut       Date:  1988-07       Impact factor: 23.059

7.  Increased gastric juice epidermal growth factor after non-steroidal anti-inflammatory drug ingestion.

Authors:  S M Kelly; J R Jenner; R J Dickinson; J O Hunter
Journal:  Gut       Date:  1994-05       Impact factor: 23.059

8.  Immunohistochemical localization of epidermal growth factor in the second-trimester human fetus.

Authors:  S S Poulsen; N Kryger-Baggesen; E Nexø
Journal:  Histochem Cell Biol       Date:  1996-02       Impact factor: 4.304

9.  Systemic treatment with recombinant human epidermal growth factor accelerates healing of sclerotherapy-induced esophageal ulcers and prevents esophageal stricture formations in pigs.

Authors:  C O Juhl; L Vinter-Jensen; L S Jensen; E Nexø; J C Djurhuus; E Z Dajani
Journal:  Dig Dis Sci       Date:  1994-12       Impact factor: 3.199

10.  Recombinant human epidermal growth factor treatment of radiation-induced severe oral mucositis in patients with head and neck malignancies.

Authors:  J P Hong; S-W Lee; S Y Song; S D Ahn; S S Shin; E K Choi; J H Kim
Journal:  Eur J Cancer Care (Engl)       Date:  2009-04-23       Impact factor: 2.520
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