Nagarjuna Sivaraj1, Rachel K V2, Tarun Kumar Suvvari3, Shilaja Prasad4, Sri Harsha Boppana5, Pradeep Kumar Vegi6. 1. Department of Biochemistry & Bioinformatics, GITAM Deemed to be university, Visakhapatnam, Andhra Pradesh, India. Electronic address: nagarjuna.sivaraj@gmail.com. 2. Department of Biochemistry & Bioinformatics, GITAM Deemed to be university, Visakhapatnam, Andhra Pradesh, India. Electronic address: rachel.kv@yahoo.com. 3. Dr. N.T.R. University of Health Sciences, Andhra Pradesh, India. Electronic address: tarunkumarsuvvari234@gmail.com. 4. Department of Obstetrics and Gynecology, Great Eastern Medical School & Hospital, Ragolu, Srikakulam, India. 5. Great Eastern Medical School & Hospital, Ragolu, Srikakulam, India. Electronic address: sriharshaboppana2@gmail.com. 6. Department of Biochemistry, Great Eastern Medical School & Hospital, Ragolu, Srikakulam, India. Electronic address: pradeep.vegi@yahoo.com.
Abstract
BACKGROUND: Association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women. METHODOLOGY: The study was a case-control study with 304 pregnant women comprising of preeclampsia (n = 152) and normotensive pregnancies (n = 152). And SNP rs2071374 was genotyped by PCR-RFLP method. RESULTS: The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia P = 0.01741, odds ratio = 0.7006 (95% CI: 0.5023-0.9759). CONCLUSION: The results indicated that there was an association in IL1R1 rs2071374SNP with preeclampsia compared to non-preeclampsia women. It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India.
BACKGROUND: Association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women. METHODOLOGY: The study was a case-control study with 304 pregnant women comprising of preeclampsia (n = 152) and normotensive pregnancies (n = 152). And SNP rs2071374 was genotyped by PCR-RFLP method. RESULTS: The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia P = 0.01741, odds ratio = 0.7006 (95% CI: 0.5023-0.9759). CONCLUSION: The results indicated that there was an association in IL1R1 rs2071374SNP with preeclampsia compared to non-preeclampsia women. It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India.