Literature DB >> 34923167

The protective role of exercise against age-related neurodegeneration.

Alyson Sujkowski1, Luke Hong2, R J Wessells3, Sokol V Todi4.   

Abstract

Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to multiple organ systems. Exercise improves multiple indices of physical performance and stimulates pronounced health benefits reducing a range of pathologies including metabolic, cardiovascular, and neurodegenerative disorders. Endurance exercise delays brain aging, preserves memory and cognition, and improves symptoms of neurodegenerative pathologies like Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, and various ataxias. Potential mechanisms underlying the beneficial effects of exercise include neuronal survival and plasticity, neurogenesis, epigenetic modifications, angiogenesis, autophagy, and the synthesis and release of neurotrophins and cytokines. In this review, we discuss shared benefits and molecular pathways driving the protective effects of endurance exercise on various neurodegenerative diseases in animal models and in humans.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Exercise; Mitochondria; Muscle; Neurodegeneration; Proteinopathy

Mesh：

Year:  2021        PMID： 34923167      PMCID： PMC8761166          DOI： 10.1016/j.arr.2021.101543

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   10.895


  307 in total

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2.  A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women.

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3.  Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).

Authors:  Ivelisse Sánchez; Eudald Balagué; Antoni Matilla-Dueñas
Journal:  Hum Mol Genet       Date:  2016-07-27       Impact factor: 6.150

Review 4.  Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology.

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Journal:  Essays Biochem       Date:  1995       Impact factor: 8.000

Review 5.  DNA damage and its links to neurodegeneration.

Authors:  Ram Madabhushi; Ling Pan; Li-Huei Tsai
Journal:  Neuron       Date:  2014-07-16       Impact factor: 17.173

Review 6.  Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease.

Authors:  B P Brooks; K H Fischbeck
Journal:  Trends Neurosci       Date:  1995-10       Impact factor: 13.837

Review 7.  Polyglutamine Repeats in Neurodegenerative Diseases.

Authors:  Andrew P Lieberman; Vikram G Shakkottai; Roger L Albin
Journal:  Annu Rev Pathol       Date:  2018-08-08       Impact factor: 23.472

Review 8.  Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration.

Authors:  Khalid Bashir Dar; Aashiq Hussain Bhat; Shajrul Amin; Bilal Ahmad Reshi; Mohammad Afzal Zargar; Akbar Masood; Showkat Ahmad Ganie
Journal:  Cell Mol Neurobiol       Date:  2019-10-04       Impact factor: 5.046

9.  Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.

Authors:  Kavya Reddy; Corey L Cusack; Israel C Nnah; Khoosheh Khayati; Chaitali Saqcena; Tuong B Huynh; Scott A Noggle; Andrea Ballabio; Radek Dobrowolski
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10.  Satellite cell content in Huntington's disease patients in response to endurance training.

Authors:  Sandro Manuel Mueller; Violeta Mihaylova; Sebastian Frese; Jens A Petersen; Maria Ligon-Auer; David Aguayo; Martin Flück; Hans H Jung; Marco Toigo
Journal:  Orphanet J Rare Dis       Date:  2019-06-11       Impact factor: 4.123
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Review 2.  Molecular Mechanisms of Exercise and Healthspan.

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Journal:  Cells       Date:  2022-03-03       Impact factor: 6.600

3.  Home Aerobic Training for Cerebellar Degenerative Diseases: a Randomized Controlled Trial.

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Journal:  Cerebellum       Date:  2022-03-18       Impact factor: 3.648

4.  Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias.

Authors:  Alyson Sujkowski; Kristin Richardson; Matthew V Prifti; Robert J Wessells; Sokol V Todi
Journal:  Elife       Date:  2022-02-16       Impact factor: 8.140

5.  Effect of Wearable Sensor-Based Exercise on Musculoskeletal Disorders in Individuals With Neurodegenerative Diseases: A Systematic Review and Meta-Analysis.

Authors:  Xin Li; Zhengquan Chen; Yiming Yue; Xuan Zhou; Shuangyu Gu; Jing Tao; Haibin Guo; Meiwen Zhu; Qing Du
Journal:  Front Aging Neurosci       Date:  2022-07-26       Impact factor: 5.702

6.  Judo training program improves brain and muscle function and elevates the peripheral BDNF concentration among the elderly.

Authors:  Sylwester Kujach; Maciej Chroboczek; Joanna Jaworska; Angelika Sawicka; Miroslaw Smaruj; Pawel Winklewski; Radoslaw Laskowski
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Review 7.  Roles and Molecular Mechanisms of Physical Exercise in Sepsis Treatment.

Authors:  You Wu; Xiaofeng Guo; Yuliang Peng; Zongping Fang; Xijing Zhang
Journal:  Front Physiol       Date:  2022-06-29       Impact factor: 4.755

Review 8.  DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome.

Authors:  Samantha L Schaffner; Michael S Kobor
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9.  On Disease Modifying and Neuroprotective Treatments for Parkinson's Disease: Physical Exercise.

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10.  Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.

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  10 in total

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