We thank the authors for the response to our case series entitled “Three cases of acute venous thromboembolism in females following vaccination for COVID-19.” Previous reports have outlined thrombotic complications following COVID-19 vaccination and have suggested a possible mechanism involving an immune thrombotic thrombocytopenia mediated by platelet-activating antibody against PF4.
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Committing to a mechanism to explain this phenomenon is out of the scope of this case series, but we welcome other suggestions from our colleagues. It is possible that thrombotic events after vaccination could be due to the changes in blood viscosity and rheological change, as suggested by Mungmunpuntipantip and Wiwanitkit.
Authors: Nina H Schultz; Ingvild H Sørvoll; Annika E Michelsen; Ludvig A Munthe; Fridtjof Lund-Johansen; Maria T Ahlen; Markus Wiedmann; Anne-Hege Aamodt; Thor H Skattør; Geir E Tjønnfjord; Pål A Holme Journal: N Engl J Med Date: 2021-04-09 Impact factor: 91.245
Authors: Andreas Greinacher; Thomas Thiele; Theodore E Warkentin; Karin Weisser; Paul A Kyrle; Sabine Eichinger Journal: N Engl J Med Date: 2021-04-09 Impact factor: 91.245