Literature DB >> 3492027

Anti-C1q affinity isolated circulating immune complexes correlate with extra-articular rheumatoid disease.

R D Melsom, A C Horsfall, L Schrieber, P Charles, R N Maini.   

Abstract

Circulating immune complexes (CIC) were isolated from sera of 35 patients with rheumatoid arthritis (RA) by a two-step method using 2% polyethylene glycol precipitation and anti-C1q affinity chromatography. By this method CIC were exclusive to 19 patients with vasculitis, nodules, or Sjögren's syndrome. Levels of CIC did not correlate with the severity of synovitis but reflected the extent of extra-articular disease. Furthermore, in four patients with persistent severe synovitis observed over a period of 4 to 16 months, the levels of CIC paralleled changes in extra-articular disease. Despite such additional evidence, whether the relationship between CIC and tissue injury is causative or consequential remains unresolved.

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Year:  1986        PMID： 3492027     DOI： 10.1007/BF00541372

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  21 in total

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Authors: 
Journal:  Ann Rheum Dis       Date:  1959-03       Impact factor: 19.103

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Journal:  AMA Arch Pathol       Date:  1953-06

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Journal:  Am Rev Respir Dis       Date:  1984-09

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Authors:  K Hannestad; A Johannessen
Journal:  Scand J Immunol       Date:  1976       Impact factor: 3.487

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Authors:  R D Soltis; D E Hasz
Journal:  J Immunol Methods       Date:  1983-02-25       Impact factor: 2.303

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Authors:  B E Bourke; I K Moss; P Mumford; A Horsfall; R N Maini
Journal:  Clin Exp Immunol       Date:  1982-06       Impact factor: 4.330

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Authors:  R D Melsom; P R Smith; R N Maini
Journal:  Ann Rheum Dis       Date:  1987-02       Impact factor: 19.103

9.  Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vasculitis and circulating immune complexes.

Authors:  P J Venables; C C Erhardt; R N Maini
Journal:  Clin Exp Immunol       Date:  1980-01       Impact factor: 4.330

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Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808
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  5 in total

1.  Incidence and predictors of severe extra-articular disease manifestations in an early rheumatoid arthritis inception cohort.

Authors:  C Turesson; K Eberhardt; L T H Jacobsson; E Lindqvist
Journal:  Ann Rheum Dis       Date:  2007-11       Impact factor: 19.103

2.  Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis.

Authors:  Margalit E Rosenkranz; David C Wilson; Anthony D Marinov; Alisha Decewicz; Patrick Grof-Tisza; David Kirchner; Brendan Giles; Paul R Reynolds; Michael N Liebman; V S Kumar Kolli; Susan D Thompson; Raphael Hirsch
Journal:  Arthritis Rheum       Date:  2010-06

3.  Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis.

Authors:  C Turesson; L T H Jacobsson; G Sturfelt; E L Matteson; L Mathsson; J Rönnelid
Journal:  Ann Rheum Dis       Date:  2006-08-10       Impact factor: 19.103

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Authors:  P Christensen; A K Schröder
Journal:  Agents Actions       Date:  1990-01

5.  C1q-bearing immune complexes induce IL-8 secretion in human umbilical vein endothelial cells (HUVEC) through protein tyrosine kinase- and mitogen-activated protein kinase-dependent mechanisms: evidence that the 126 kD phagocytic C1q receptor mediates immune complex activation of HUVEC.

Authors:  S Xiao; C Xu; J N Jarvis
Journal:  Clin Exp Immunol       Date:  2001-09       Impact factor: 4.330
  5 in total

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