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Literature DB >> 34919641

The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.

Ayano Tsuru¹, Yumi Hamazaki¹, Shuta Tomida², Mohammad Shaokat Ali^1,3, Eriko Kage-Nakadai¹.

Abstract

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.

Entities: Chemical

Keywords: zzm321990 Caenorhabditis eleganszzm321990 ; zzm321990 Cutibacterium acneszzm321990 ; zzm321990 tir-1zzm321990 ; antimicrobial molecule; p38 MAPK

Mesh：

Year: 2022 PMID： 34919641 PMCID： PMC8866249 DOI： 10.1093/bbb/zbab218

Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN： 0916-8451 Impact factor: 2.043

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The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.

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