Literature DB >> 34918914

The Dawn of a New Era in Drug Discovery? Drug Screening and the Increasing Biological Complexity of Testing Models.

Wen-Jen Lin1.   

Abstract

Whole-organism phenotype screening and complex in vitro model technology increase the likelihood in identifying successful lead compounds and lower drug attrition rates at later and more expensive stages of the drug discovery process.

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Year:  2021        PMID： 34918914      PMCID： PMC9532213          DOI： 10.1021/acs.chemrestox.1c00331

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.973


  4 in total

1.  Do Zebrafish Obey Lipinski Rules?

Authors:  Keith Long; Stephen J Kostman; Christian Fernandez; James C Burnett; Donna M Huryn
Journal:  ACS Med Chem Lett       Date:  2019-04-24       Impact factor: 4.345

2.  Phase II and phase III failures: 2013-2015.

Authors:  Richard K Harrison
Journal:  Nat Rev Drug Discov       Date:  2016-11-04       Impact factor: 84.694

3.  Operationalizing the Use of Biofabricated Tissue Models as Preclinical Screening Platforms for Drug Discovery and Development.

Authors:  Olive Jung; Min Jae Song; Marc Ferrer
Journal:  SLAS Discov       Date:  2021-07-16       Impact factor: 3.341

Review 4.  The zebrafish subcortical social brain as a model for studying social behavior disorders.

Authors:  Yijie Geng; Randall T Peterson
Journal:  Dis Model Mech       Date:  2019-08-06       Impact factor: 5.758
  4 in total

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