Alexane Lere-Chevaleyre1, Maureen Bernadach2, Céline Lambert3, Lucie Cassagnes4, Mathilde Puechmaille1, Thierry Mom1, Laurent Gilain1, Michel Lapeyre5, Yves Boirie6,7, Julian Biau5, Nicolas Saroul1,6. 1. Department of Otolaryngology-Head and Neck Surgery, Clermont-Ferrand University Hospital, Clermont-Ferrand, France. 2. Medical Oncology Department, Centre Jean Perrin, Clermont-Ferrand, France. 3. Biostatistics Unit (DRCI), Clermont-Ferrand University Hospital, Clermont-Ferrand, France. 4. Department of Radiology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France. 5. Radiation Oncology Department, Centre Jean Perrin, Clermont-Ferrand, France. 6. UNH, Unité de Nutrition Humaine, CRNH, Université Clermont Auvergne, INRA, Auvergne, Clermont-Ferrand, France. 7. Clinical Nutrition Department, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Abstract
BACKGROUND: To assess the impact of nutritional status on tolerance to induction chemotherapy by docetaxel, cisplatin and 5-fluorouracil (ICT) in head and neck cancer (HNC). METHODS: Ninety-two HNC patients were included. Toxicity was assessed according to common terminology criteria for adverse events. Nutritional status was assessed by body mass index (BMI), serum albumin, nutritional risk index (NRI), and CT scan (skeletal muscle mass index [SMI] at the first lumbar vertebral level). RESULTS: Before treatment, average BMI was 22.7 ± 4.6 kg/m2 , serum albumin 38.7 ± 5.8 g/L, NRI 97.6 ± 10.6, and SMI 36.4 ± 7.9 cm2 /m2 . After treatment, BMI was 23 ± 4.5, serum albumin 30.2 ± 7.1, and NRI 88.1 ± 9.2. During ICT, 52 (62%) patients developed at least one toxicity ≥ Grade 3. Pre-treatment SMI was the only predictive factor of toxicity irrespective of BMI (p = 0.04). CONCLUSION: Low skeletal muscle mass is a predictive factor of toxicity to ICT in HNC.
BACKGROUND: To assess the impact of nutritional status on tolerance to induction chemotherapy by docetaxel, cisplatin and 5-fluorouracil (ICT) in head and neck cancer (HNC). METHODS: Ninety-two HNC patients were included. Toxicity was assessed according to common terminology criteria for adverse events. Nutritional status was assessed by body mass index (BMI), serum albumin, nutritional risk index (NRI), and CT scan (skeletal muscle mass index [SMI] at the first lumbar vertebral level). RESULTS: Before treatment, average BMI was 22.7 ± 4.6 kg/m2 , serum albumin 38.7 ± 5.8 g/L, NRI 97.6 ± 10.6, and SMI 36.4 ± 7.9 cm2 /m2 . After treatment, BMI was 23 ± 4.5, serum albumin 30.2 ± 7.1, and NRI 88.1 ± 9.2. During ICT, 52 (62%) patients developed at least one toxicity ≥ Grade 3. Pre-treatment SMI was the only predictive factor of toxicity irrespective of BMI (p = 0.04). CONCLUSION: Low skeletal muscle mass is a predictive factor of toxicity to ICT in HNC.
Authors: Aniek T Zwart; Wolf Pörtzgen; Irene van Rijn-Dekker; Grigory A Sidorenkov; Rudi A J O Dierckx; Roel J H M Steenbakkers; Inge Wegner; Anouk van der Hoorn; Geertruida H de Bock; Gyorgy B Halmos Journal: J Clin Med Date: 2022-08-09 Impact factor: 4.964