Humanistic and Economic Burden of Geographic Atrophy: A Systematic Literature Review.

PURPOSE: Geographic atrophy (GA), the advanced form of dry age-related macular degeneration, can result in irreversible blindness over time. We performed a systematic literature review to assess the humanistic and economic burden of GA.
METHODS: Predefined search terms were used to identify studies in PubMed, Embase, and Cochrane Library; conference abstracts also were searched.
RESULTS: Of 1111 unique studies identified, 25 studies on humanistic burden, 4 on economic burden, and 3 on both humanistic and economic burden of GA were included. Vision-related functioning and health-related quality of life (HRQOL) are poor in patients with GA. HRQOL is commonly measured using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25); patients with GA have significantly lower composite and subscale scores for near activities, distance activities, dependency, driving, social functioning, mental health, role difficulties, color vision, and peripheral vision than individuals without GA. Driving is a particular concern, and inability to drive affects dependency. Vision-related quality of life (VRQOL) declines as GA progresses. While we identified only 7 reports describing the economic burden of GA, its direct costs may be substantial. In a US study, mean cost to the payer per patient with GA was $11,533 in the year after diagnosis. A multinational study estimated annualized total direct costs of €1772 per patient with GA, mainly driven by diagnostic tests and procedures (€1071). Patients with GA are at increased risk of falls and fractures, potentially increasing direct costs. Only one study evaluated indirect costs, estimating ~$24.4 billion in yearly lost wages among people with severe vision loss due to GA or drusen ≥125 μm.
CONCLUSION: GA represents a significant humanistic burden. Evidence on the economic impact of GA is limited; characterizing the economic burden of GA requires further research. Interventions that reduce GA-related disability may improve HRQOL and reduce indirect costs.

Introduction

Geographic atrophy (GA) is generally defined as the advanced or late stage of dry age-related macular degeneration (AMD) with a circular area of atrophy of 175 μm or more.1,2 However, minimum sizes to define atrophic patches vary.2 In contrast to neovascular AMD, which is characterized by acute vision loss, GA is a progressive disease that can lead to irreversible blindness over time.1 GA interferes with daily activities such as driving, reading, writing, and recognizing faces, and in turn, negatively affects quality of life, potentially impairing mobility and independence.3–5 The incidence of GA is not well understood, as it is likely underdiagnosed and underreported. A meta-analysis of US populations of white European ancestry reported incidence rates of 1.9 per 1000 person-years (95% confidence interval [CI], 1.3–2.8) for adults aged 50–97 years and 4.3 per 1000 person-years (95% CI, 2.9–6.2) for adults aged ≥65 years.6 An estimated 12–20% of patients with GA have severe vision loss,7 potentially requiring caregiver help with transportation and activities of daily living.

Several nonmodifiable and modifiable risk factors are associated with development of GA and risk of disease progression.1,8,9 A number of genetic polymorphisms of the complement components and its regulators have been shown to be risk factors for developing AMD.8,9 Age and family history are significant risk factors for developing GA; cigarette smoking, diet pattern, physical activity level, and health conditions including hypertension, hyperlipidemia, obesity, and other ophthalmic comorbidities (eg, diabetic retinopathy and glaucoma) also have been reported to correlate with GA onset.1,4,8 No effective treatments are indicated to prevent or slow the progression of GA; consequently, it has a poor prognosis.10 Currently, the only potential approach to preventing GA is avoiding modifiable risk factors such as smoking and maintaining a healthy lifestyle.1,8

To describe the burden of illness of GA and identify evidence gaps in the literature, we conducted a systematic literature review focusing on the humanistic and economic burden of disease and health-care resource use. The clinical burden of GA was also evaluated in this review but is not reported here.

Materials and Methods

A systematic literature review was conducted to identify studies indexed in PubMed, Embase, EconLit, and Cochrane Library. Abstracts from relevant congresses (American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, and European Association for Vision and Eye Research) were searched for 2019–2021 to identify recent information not yet indexed in medical literature databases. Additional data sources included bibliographies of included systematic reviews and meta-analyses, the grey literature, and clinical trials for emerging therapeutic agents for GA via ClinicalTrials.gov using the search term “geographic atrophy.” Search terms included combinations of free text and Medical Subject Headings or Emtree subject headings. Two sets of searches were conducted: the first searches identified studies published from January 1, 2010–August 11, 2020. Because very little evidence on the humanistic or economic burden of GA during this window was identified, a second set of searches identified studies on the humanistic or economic burden of GA published from January 1, 2005–January 22, 2021. Studies were chosen in accordance with predefined eligibility criteria; additional details regarding the search methodology are presented in –, . Relevant data were extracted directly from the identified studies. Costs presented in the included studies were converted, as applicable, to US dollars (USD) in the reported cost year; all costs were then inflated to 2020 USD. Exchange rates and inflation factors were taken from the Organization of Economic Co-Operation and Development website;11 additional details are presented in and , . No additional analyses across studies were produced.

Results

Search Results

Of 1111 unique studies identified, 142 were included in the broader systematic literature review (, ). Of these, 32 studies were included in the review: 25 on the humanistic burden, 4 on the economic burden, and 3 on both humanistic and economic burdens.

Humanistic Burden

Table 1 summarizes studies describing the humanistic burden of GA. Most used the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) to describe the burden of GA.

Table 1

Clinical Trial and Observational Studies Describing the Patient Burden of Geographic Atrophy

Study, Country	Study Type and Objective	Patient Numbers and Characteristics	Instrument	Key Results	Conclusions
Ahluwalia et al (2021)23 andAhluwalia et al. (2020)24 US	Longitudinal study (subset of patients in AREDS) of natural progression of VRQOL in GA	n=206 and n=259 patients with central GA	NEI VFQ-25	Median time to clinically meaningful decline in VRQOL (loss of 5 points) was 4.2 years	After developing advanced AMD, patients continue to experience a decline in VRQOL
Borkenstein and Borkenstein (2020)28 Austria	Observational study of patients with GA undergoing magnifying cataract surgery	N=11 patients with GA	Questionnaire listing 10 routine activities	10 of 11 patients reported limitations in their ability to complete routine activities (from the list of reading, recognizing photos, eating and cooking, operating a telephone, daily hygiene rituals, brushing teeth, cutting nails, operating household appliances, manual work, and use of low-vision aids)	Patients with GA are limited in their activities of daily living
Carlton et al. (2019)27 UK	Focus group study to determine impact of GA on daily activities	N=9 patients with GA	Focus group discussion	The overarching themes identified were experience of symptoms and understanding of GA, impact on activities, feelings and emotions, relationships and informal support, accessing formal support, and information needs	GA impacts many activities of daily living, and patients also experience emotions such as fear, frustration, and worry about loss of independence
Higgins et al. (2020)30 UK	Study to investigate performance in novel computer-based tasks in individuals with non-neovascular AMD	n=11 individuals with no macular diseasen=16 individuals with nAMDn=22 individuals with GA	N/A	Participants with GA recorded slower response times for performing visual searches for everyday objects and had fewer correct responses; >50% performed outside the normal limit for task performance	Increasing severity of disease was associated with longer response time and fewer correct responses
Rohart et al. (2008)29 France	Prospective study investigating the effects of cataract surgery of visual functioning	Subgroup (n=12) with GA and neovascularization (advanced AMD)	VF-14	The mean preoperative VF-14 score was 44/100 in postoperative patients (Note lower score indicated worse visual functioning)	Patients with GA and neovascularization had impaired visual functioning even after removal of the cataract
Sunness et al. (2008)31 US	Natural history study of GA conducted 1992–2000Objective was to investigate reading difficulties and progression of reading rates and VA	156 patients with GA who had VA of 20/50 or better (logMAR VA <0.46) in one or both eyes with GAPatients had scotomas with central sparing	NA	Reading speed was affected by the type of GA in patients with scotomas in the central field, but with central sparing that was partially or completely surrounded by scotomas	Reading speed is affected by GA
Sunness et al. (2008)32 US	Natural history study of GA conducted 1992–2000Objective was to show that low-luminance visual dysfunction is predictive of subsequent VA	Subset of 91 patients with GA who completed a 2-year study examination	NA	LLVA deficit at baseline and reading rate were found to be a significant risk factor for subsequent loss of VA (relative risk, 2.43 [95% CI, 1.11–5.31])	Patients with GA can experience LLVA and low reading rate
Burguera-Giménez et al. (2020)21 Spain	Observational study to evaluate visual function in GA versus healthy eyes	Total 63 eyesGA: 32Healthy: 31Age, mean (SD), yGA: 78.53 (8.11)Control: 65.42 (7.86)	NEI VFQ-25	In the GA group, there were moderate and strong correlations between the following and the VFQ-25 composite score:Maximum reading speed (r=0.787; P<0.01)Contrast sensitivity spatial frequency 3 cpd (r=0.0441; P<0.05)Macular sensitivity (r=0.484; P<0.05)Atrophic area (r=−0.689; P<0.01)Reading speed, contrast sensitivity, fixation, and macular sensitivity were strongly associated with VRQOL	There was a decrease in composite score and significant reduction in all subscales tested in the GA group versus the control group (P ˂ 0.01)The decreased visual function was reflected in poor QOL in patients with GA
Künzel et al. (2020)38 Germany	Longitudinal study of VRQOL in GA secondary to AMD and in relation to visual function and structural biomarkers (Directional Spread in Geographic Atrophy Study, NCT02051998)	Cross-sectional:87 patients with GA secondary to AMDAge, mean (SD), y: 77.07 (7.49)Longitudinal:66 patients with GAMedian (IQR) 2 (2) visits followed-up for 1.08 (0.78) y	NEI VFQ-25	In the multivariate cross-sectional analysis, predictors of VRQOL composite score were BCVA, GA lesion size, and LLVA for the better eye and BCVA, foveal sparing status, and LLVA for the worse eyeThe multivariate longitudinal analysis showed that the LLVA of both eyes, the reading acuity of both eyes, and the BCVA, GA lesion size, and foveal sparing status of the better eye were important predictors of the VRQOL composite score.Similar results were obtained for the near and distant vision subscales	For clinical trials designed to prove benefits in VRQOL, treatment should be allocated to the better eye.The cross-sectional and longitudinal association of VRQOL with visual functional and structural biomarkers supported the validity of the NEI VFQ-25 VRQOL.
Orr et al. (2016)39 US	To assess the effects of impaired visual acuity associated with GA (baseline scores in a Phase 1/2 study)	N=32 patients with moderate to severe GA secondary to AMD:53% femaleAge, mean (SD), y: 81 (7)Maximum reading speed in treated eye, mean (SD): 32 (35) words per minuteGA area 16 (SD 9) mm	NEI VFQ-25	At baseline, there were decrements in many subscales. The lowest scores were these:General vision (eyesight)Near activities (difficulty with close-up activities)Role difficulties (impact in ability to accomplish tasks and activity limitations)Driving (for those patients still driving)	GA negatively affects HRQOL, with decrements in many areas
Patel et al. (2020)22 UK, Canada, Germany, Ireland	Cross-sectional study to compare vision-related functioning and QOL in patients with GA due to AMD versus control group	GA group (n=137): patients aged ≥70 y with physician-confirmed bilateral symptomatic GANon-GA group (n=52): patients of similar age with no ophthalmic condition that in the opinion of the investigator affected visual function	NEI VFQ-25	Vision-related functioning and QOL were worse in patients with GA vs patients without GA: significantly lower composite score (mean, 53.1 vs 84.5 points; P<0.001) and lower subscale scores for near activities, distance activities, dependency, driving, social functioning, mental health, role difficulties, color vision, and peripheral visionGeneral health was similar between groupsGA group vs non-GA group: more patients reported worsening in vision over the past year (82% vs 25%; odds ratio, 13.55; P<0.001)Driving: 55% of patients with GA had a driver’s license, but 52% of these patients did not drive during the day and most (88%) did not drive at night. Eyesight was reported as the most common reason for giving up driving in the GA group (81%)	Patients with GA experience a poorer level of vision-related function and QOL than controls (their peers), especially in relation to driving
Patnaik et al. (2019)40 US	Cross-sectional study to measure VRQOL in patients with AMD (including GA)	n=594 patientsPatient categories:Early/intermediate AMD (n=207)Advanced nAMD (n=113)GA (n=95)Advanced nAMD in one eye and any-stage dry AMD in the other (both) (n=179)Controls (n=306)	NEI VFQ-25	Composite scores were highest in patients with early/intermediate dry AMD (90.2), followed by controls (83.1),patients with both (81.7), GA (77.0), and advanced nAMD (72.1) had the lowest overall mean scoresTypically, patients with early/intermediate AMD and controls had higher scores compared with the three advanced AMD groups, particularly nAMD and GAThe greatest differences between groups were seen in subscales of mental health, role limitations, dependency, and driving. Lower discrepancies were observed in subscales of general health, general vision, social functioning, color vision, and peripheral vision	Composite scores for patients with GA and advanced nAMD were much lower (worse) than for patients with earlier disease
Patnaik et al. (2020)20 US	Cross-sectional study to measure visual function and VRQOL in patients with AMD (including GA)	N=739Patient categories:Early/intermediate AMD (n=294)Advanced nAMD (n=168)nAMD with GA (n=162)GA (n=115)Patients were stratified into unilateral and bilateral disease	NEI VFQ-25	Composite scores were highest in patients with early/intermediate AMD and lowest in patients with bilateral disease that included GAIn general, this pattern of scores persisted across subscalesThe lowest score was for driving in the group of patients with bilateral advanced disease that included GA	Large differences in visual function were seen across different AMD groups and number of eyes affected with AMDPatients with bilateral disease that included GA had the lowest scores for visual functioning and VRQOL
Singh et al. (2019)5 US	Cross-sectional qualitative study to understand the burden of illness of GA from patient, caregiver, and eye care professional perspectives	Patients with symptomatic GA (n=8), their caregivers (n=6), and eye care professionals (n=5)	Semi-structured interview	The following areas were affected:Patients: Social and psychological factors, helplessness, impact on sports/hobbies, meals or food preparation, religious activities, and long-distance travel. Stopping driving or changing driving patterns was a major concern. 38% of patients modified work schedules due to vision impairment.Caregivers: Modification of schedules, frustration at inability to improve patient’s conditionClinicians: Emotional and mental impact of vision loss, accidents, and injuries	GA has a major negative effect on patients’ and caregivers’ social functioning and HRQOL
Sivaprasad et al. (2019)25 US, UK, Germany	Cross-sectional ethnographic observational study conducted to understand the impact of bilateral GA on daily functioning	Trained ethnographers visited the patients in their home environment to contextualize their lived experience through discussion (interviews) and observationN=16Age, mean (SD), y: 80 (7.3)Female, n=10 (62.5%); male, n=6 (37.5%)	NEI VFQ-25 and semi-structured interview guide with questions on daily routine and challenges faced due to visual function deterioration	Interview: Functional impact domains affecting 2 or more patients:Activities of daily living: difficulty reading (n=16); driving (n=12); and watching movies, television, or theatre (n=11)Emotional: frustration (n=7) and fear of blindness (n=7)Social/leisure: interference with hobbies such as playing cards, sewing, playing golf, birdwatching, taking photographs, and woodworking (n=8) and diminished social activities (n=4)Physical: walking into things, tripping or falling (n=4)Financial (n=10)Patients also reported loss of independence (n=9), difficulty recognizing faces (n=10), and difficulty performing household activities such as chores and cooking (n=10).The mean (SD) NEI VFQ-25 composite score was 67 (17) on a scale of 0 (worst) to 100 (best); a mean score of <60 was obtained for general vision and both near and distance activities; mean (SD) driving score was the lowest at 22 (32).	All patients reported that GA affected activities of daily living, particularly reading; driving; watching television, movies, or theatre; recognizing faces; and performing household activities. Most patients also reported financial and social impacts
Wang et al. (2015)41 Country not reported	A randomized, double-masked, placebo-controlled trial to assess baseline patient-reported visual function for patients with GA entering a clinical study and association between BCVA and GA lesion size	N=191Age, average (SD), y: 77.2 (8.6)Lesion area, average (SD), mm: 7.7 (4.6)BCVA, average (SD), letters: 62.7 (14.8)	NEI VFQ-25	Mean scores at screening showed a relationship with worsening BCVA and larger GA areaThe most significant decrements in composite and 6 subscale scores occurred between the >20/40 and 20/40–20/80 subgroups	Patients with GA have significant impairment in many aspects of visual function. The decrement in function is greater during early vision loss and as GA lesion size crosses a median value of 6.6 mm2.

Abbreviations: AMD, age-related macular degeneration; AREDS, Age-Related Eye Disease Study; BCVA, best corrected visual acuity; cpd, cycles per degree; GA, geographic atrophy; HRQOL, health-related quality of life; IQR, interquartile range; LLVA, low-luminance visual acuity; logMAR, logarithm of the minimum angle of resolution; NA, not applicable; nAMD, neovascular age-related macular degeneration; NEI VFQ-25, National Eye Institute Visual Function Questionnaire; QOL, quality of life; SD, standard deviation; UK, United Kingdom; US, United States; VA, visual acuity; VF-14, Visual Function Index 14; VRQOL, vision-related quality of life.

Measurement of Quality of Life and Reading Function in GA

Three patient-reported outcome measures are commonly used in prospective trials of GA (see ). Briefly, the validated patient-reported NEI VFQ-25 is commonly included in studies in AMD to evaluate disease burden and has undergone preliminary validation in patients with GA,12 although Rasch analysis has shown it not to be psychometrically valid in its native form.13 The Visual Function Index 14 (VF-14) questionnaire was originally developed to assess the functional impairment caused by cataract,14 but has since undergone preliminary validation for use in patients with AMD,15 specifically neovascular AMD (nAMD),16 although not in patients with GA. The Functional Reading Independence (FRI) Index is a new seven-item instrument developed to assess the functional impact of GA.17

More broadly, in AMD, standardized measurement of outcomes, including measurement of vision-related quality of life (VRQOL), has been advocated by the International Consortium for Health Outcomes Measurement (ICHOM) working group. Specifically, the ICHOM has recommended that the brief Impact of Vision Impairment (IVI) questionnaire, which has appropriate content and reliability in patients with AMD (including those with late AMD) and has also undergone Rasch analysis and psychometric validation, should be used to assess visual functioning and VRQOL in patients with AMD.18,19

Impact of GA on Vision- and Health-Related Quality of Life

Several studies have evaluated VRQOL and health-related quality of life (HRQOL) in GA relative to other ocular conditions. Quality of life in patients with GA, as assessed by the NEI VFQ-25, was shown in a cross-sectional US study to be worse than that in patients with early/intermediate AMD and nAMD.20 A study of 739 patients with AMD showed that mean composite scores were highest among early/intermediate patients (89.9) and lowest for the groups with bilateral GA (71.3) and bilateral GA plus nAMD (68.5). Overall, patients with bilateral disease consistently had lower mean scores than their unilateral counterparts. In addition, an observational study in Spain evaluated visual function and VRQOL using the NEI VFQ-25 in 63 study eyes in 63 patients ≥50 years old. Thirty-two eyes were identified as having GA and 31 eyes had normal macular health. For composite scores and all subscales, mean NEI VFQ-25 scores for the GA group were statistically significantly lower (worse) than that for the control group.21 A cross-sectional study comparing the HRQOL of patients with GA (n = 137) with patients of similar age with no ophthalmic conditions (n = 52) showed that GA is associated with a reduction in HRQOL. Patients in the GA group had a significantly lower mean (standard deviation [SD]) NEI VFQ-25 composite score than those in the non-GA group (53.1 [19.05] vs 84.5 [6.55] points, respectively; P < 0.001).22

Geographic atrophy affects multiple aspects of VRQOL and HRQOL. A US cross-sectional qualitative study explored the burden of illness of GA from the perspectives of patients (n = 8), caregivers (n = 6), and eye care professionals (n = 5).5 Topics mentioned most frequently by patients were driving, reading, and psychological issues. One-fourth of patients mentioned curtailing long-distance trips, 63% reported difficulty reading for everyday tasks or leisure, and 38% felt helpless or embarrassed that they required assistance. All patients reported that they still performed household chores, but they sometimes took longer to complete. Caregivers provided comments similar to those of patients, citing frustration at watching patients struggle. Caregivers provided transportation, assisted with household tasks, and offered help. Caregivers linked injuries to GA even when the patients did not.5 Eye care professionals reported that they routinely screened for psychological well-being, and suggested that patients in urban areas have less difficulty getting around due to public transportation, while patients in rural areas are more isolated.5

Evidence suggests that VRQOL in patients with GA declines over time as the disease progresses. The rate of decline in VRQOL was assessed using the NEI VFQ-25 in patients with central GA in the US AREDS study.23,24 A clinically meaningful decrease in VRQOL was defined as a loss of 5 points, and the median time to significant loss of VRQOL was 4.2 years (95% CI, 3.0–5.7 years) in 259 patients,24 corresponding to a decline in 1.68 ± 4.65 NEI VFQ-25 units/year (107 patients).23

Impact of GA on Functioning and Visual Performance

Geographic atrophy has a profound effect on patient functioning and activities of daily living and can limit independence. Sivaprasad et al25 investigated the impact of GA on daily routine activities of 16 patients with GA in Germany, the United Kingdom (UK), and the US. Patients reported difficulties with reading (100%), driving (75%), and watching television, films, or theatre (68.8%). Other concepts reported included loss of independence (56.3%) and difficulty in recognizing faces (62.5%) or performing household activities (62.5%).25

A retrospective cohort analysis in the UK of 1901 patients with bilateral GA found that over time, 16% of patients became legally blind (median time to progression of 6.2 years [interquartile range (IQR), 3.3–8.5]) and 66.7% became ineligible to drive (median time to progression of 1.6 years [IQR, 0.7–2.7]), indicating the degree of the visual disability associated with GA.26 Results from a small focus group study of 9 UK patients with GA confirmed its impact on activities of daily living and reading. Visual symptoms such as blurring, distortion, and changes in perception affected activities such as driving, traveling as a passenger in a car, and walking; several participants had given up driving.27 Reading for both pleasure and necessity (eg, reading menus or card machines) was also impacted by GA. Other activities that participants had given up, or reported difficulties with, because of the symptoms of GA were housework, sewing and craft, puzzles, reading, music, and watching television. Furthermore, many of the participants worried about losing independence and becoming reliant on others.

Borkenstein and Borkenstein28 reported a study of 11 Austrian patients with GA who underwent magnifying cataract surgery using a foldable, bifocal high-add intraocular lens (IOL) in the better-seeing eye. When completing a questionnaire listing 10 routine activities (reading, recognizing photos, eating and cooking, operating a telephone, daily hygiene rituals, brushing teeth, cutting nails, operating household appliances, manual work, and use of low-vision aids [eg, magnifying glasses]) at 6 months postsurgery, 10 of 11 patients reported limitations in their ability to complete these activities.

A prospective French study of 12 eyes compared visual performance precataract and postcataract surgery; assessment included measurement of visual impairment using the VF-14 instrument.29 The study participants included a group (n = 12) with GA and neovascularization (advanced AMD), among whom the mean postoperative VF-14 score was 44 of 100, indicating that the patients’ visual performance was limited, even after removal of the cataract.29

Higgins conducted a study to investigate performance in novel, computer-based tasks of everyday visual functioning in UK individuals with no macular disease (n = 11), nAMD (n = 16), or GA (n = 22). Participants with GA recorded slower response times than other groups for performing visual searches for everyday objects and had fewer correct responses; >50% performed outside the normal limit for task performance.30 However, visual and reading acuity do not necessarily reflect functional reading ability in patients with GA and may depend on the location of atrophy.31,32 Sunness et al31 conducted a study of 156 US patients with GA who had visual acuity of 20/50 or better (logMAR visual acuity <0.46) in one or both eyes with GA to explore reading difficulties and the progression of reading impairment. Reading speed was affected by the pattern of GA, such that patients with scotomas in the central field, but with central sparing that is partially or completely surrounded by scotomas, had greater difficulty with larger letter sizes and reading from line to line because the words may not fit within the small central area that is surrounded by scotomas.31 Further, low reading rate was found to be a significant risk factor for subsequent loss of visual acuity (relative risk, 2.43 [95% CI, 1.11–5.31]).32

Depression and Visual Performance

A US prospective cohort study of 51 older patients with recent-onset bilateral AMD evaluated Center for Epidemiological Studies Depression Scale (CES-D) scores, visual acuity, Functional Vision Screening Questionnaire scores, Chronic Disease Score, and the Community Disability Scale.1,33 Results showed that 17 patients (33%) were depressed at baseline and had worse acuity (P = 0.04) and greater levels of vision-specific (P = 0.03) and general (P = 0.002) physical disability than nondepressed patients. However, the correlations of CES-D score with visual acuity and visual-specific disability were not significant after controlling for general physical disability. An increase in depressive symptoms over time predicted a decline in self-reported visual function independent of changes in visual acuity or medical status (P < 0.05).33

Economic Burden

Direct Costs and Health Care Resource Use

While limited evidence on the economic burden of disease is available, direct costs for patients with GA can be substantial. In a US retrospective study (N = 14,421), mean total first-year cost postdiagnosis per patient with GA to the health-care system was US $11,672 (Figure 1).34 Moreover, patients with GA are at risk of falls and fractures, which generate costs. Among all patients with GA, approximately 9% had a diagnosis of a fall or fracture during the follow-up period. The adjusted odds of developing fractures were significantly higher in patients with unilateral GA compared with those with unilateral early or intermediate AMD (odds ratio, 1.553 [95% CI, 1.073–2.242]) after adjustment for baseline characteristics and comorbidities.4 In another US study with a prospective cohort design, Anastasopoulos et al35 explored the relationship between AMD and incident hip fractures in the Medicare population and found that Medicare patients with a code for atrophic AMD had an 11% increased risk (odds ratio, 1.11 [95% CI, 1.06–1.16]; P < 0.001) of hip fractures than patients without a code for AMD over a 4-year follow-up period.

Figure 1

All-cause health care resource use (first year) by patients with GA in the United States.

Patients with GA incur variable resource use and costs, which are influenced by the presence of other ocular conditions; there is a lack of treatments and management strategies for GA. A retrospective analysis of data from medical records at different clinical sites in the UK was obtained to estimate per-patient direct ophthalmic resource use in patients with GA (N = 1080).3 Patients were divided into the following subgroups: GA in both eyes (GA:GA); GA in one eye, choroidal neovascularization (CNV) in the fellow eye (GA:CNV); and GA in one eye with early/intermediate AMD in the fellow eye (GA:E). Resource use was estimated for direct ophthalmology-related visits and associated costs (Figure 2).3 The most common monitoring test was visual acuity, followed by optical coherence tomography; both were most frequently performed in patients in the GA:CNV subgroup. This study did not include other direct costs such as the costs of anti-VEGF therapies, and it is assumed that the higher costs associated with GA:CNV were due to more frequent monitoring of CNV. It was assumed that the monitoring of GA may have occurred for non–AMD-related pathology such as glaucoma, which was more common in the GA:GA and GA:E groups than in the GA:CNV group.3

Figure 2

Median monitoring costs over 2 years across GA subgroups.

In Europe, a retrospective chart review study investigated health-care resource use among patients in the UK, Germany, Ireland, and Canada with bilateral symptomatic GA versus a non-GA control group.22 The annualized total cost, consisting of direct ophthalmic health-care resource use, was $2115 per patient with GA, mainly driven by diagnostic tests and procedures ($1278 per patient) (Figure 3). The annualized average direct total cost per patient with GA in this study ($2115) was comparable to direct vision-related medical costs reported for patients with neovascular AMD before anti-VEGF agents were approved in the UK ($3742).22,36 The total annual health-care cost for UK patients with AMD was $9214; the cost of needing assistance with activities of daily living was the highest single contributor to the annual health resource utilization costs for patients with AMD [$4434].36 These studies suggest that GA is likely to be associated with large indirect costs, the extent of which is unclear given limited research on this topic.

Figure 3

Medical and nonmedical resource utilization in the geographic atrophy group.

Indirect Costs

To estimate the economic burden of visual loss from AMD in the US, Brown et al37 used data from the US Bureau of Labor and Statistics (accessed in 2004) that revealed that the employment rate was 30.6% for those with AMD and severe visual limitation (neovascular AMD, GA, or both). According to 1997 US mean wage data, a person with disabilities, such as mild visual loss and severe visual loss, earns 30% ($15,127 salary decrease) and 38% less ($19,124 salary decrease), respectively, than the mean wage. Assuming that 10% of the US Medicare population (aged ≥65 years) have full-time employment and considering the prevalence of AMD in the US, the authors estimated a yearly loss to the US gross domestic product due to lost wages among people with severe vision loss due to GA or drusen ≥125 μm to be approximately $39.4 billion, not considering other costs such as transportation, caregivers, and injuries (Figure 4).

Figure 4

Annual loss to the US gross domestic product due to GA or drusen ≥125 μm in diameter.

Costs to Patients and Caregivers

Patients and caregivers incur out-of-pocket costs; for US patients, these included vision aids such as magnifying systems, flashlights, or talking watches. Caregivers usually provided transportation and helped with household chores.5 A US retrospective cohort study of administrative claims data (n = 14,421) from 2015 to 2018 determined the mean cost to the patient with GA to be $2863 (adjusted to 2020 USD). However, no contributing factors to the burden of GA were described.34

Discussion

Geographic atrophy is a chronic, progressive condition with no effective treatment, resulting in a poor prognosis and significant unmet needs.10 Evidence related to the humanistic burden of GA consistently uses the NEI VFQ-25, which has undergone preliminary validation in patients with GA, although a minimum clinically important difference in score changes is not yet available. The humanistic burden of GA over time requires further research, and there are also gaps in the evidence characterizing the effect of vision loss on patient functioning. The FRI Index has been used to assess the impact of GA on functional reading independence, demonstrating good reliability and validity in a small study in patients with GA (N = 100);17 further validation work will be required. In addition, very little information was identified on the humanistic effect on caregivers.

There are gaps in the evidence documenting the economic burden of GA. Our review identified only 7 studies with heterogeneous methodologies reporting on resource utilization and costs associated with GA, and no economic models. We identified only one study, published in 2005, on indirect costs. The need for more evidence on productivity impacts and indirect costs of GA is of particular importance because the societal costs of the disease are currently not well understood and could be significant.37 Further, assuming that the incidence of GA increases with age, current-day indirect costs are likely to exceed the estimates in the available published evidence.

Conclusion

In conclusion, GA represents a significant unmet need. There currently are no effective treatments, and the humanistic burden, economic burden, and unmet needs are not well understood. Interventions that reduce the disability caused by GA would potentially preserve patients’ and caregivers’ quality of life and could also reduce indirect costs associated with poor vision and blindness. Future research to determine the true economic burden of GA would enable payers to make more robust decisions regarding the value of future treatment options.