Literature DB >> 34914063

In Silico Design of Recombinant Chimera T Cell Peptide Epitope Vaccines for Visceral Leishmaniasis.

Amanda Sanchez Machado1, Vivian Tamietti Martins1, Maria Victoria Humbert2, Myron Christodoulides3, Eduardo Antonio Ferraz Coelho1.   

Abstract

Visceral leishmaniasis (VL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. Systemic VL is fatal if untreated and there are no prophylactic human vaccines available. Several studies suggest that Th1 cell-mediated immunity plays a major role in protecting against VL. In this chapter we describe a method for designing recombinant chimera vaccines in silico based on the prediction of T cell epitopes within protein antigens identified as potential protective immunogens. Development of a recombinant chimera protein (RCP) vaccine using T cell epitope peptides identified from four Leishmania proteins is used as an exemplar of this method.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Chimera; Peptide; Recombinant protein; T cell epitopes; Visceral leishmaniasis

Mesh：

Substances：

Year:  2022        PMID： 34914063     DOI： 10.1007/978-1-0716-1884-4_24

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  14 in total

1.  Increased nonobese diabetic Th1:Th2 (IFN-gamma:IL-4) ratio is CD4+ T cell intrinsic and independent of APC genetic background.

Authors:  Syuichi Koarada; Yuehong Wu; Grace Olshansky; William M Ridgway
Journal:  J Immunol       Date:  2002-12-01       Impact factor: 5.422

2.  A recombinant fusion protein displaying murine and human MHC class I- and II-specific epitopes protects against Leishmania amazonensis infection.

Authors:  Vívian T Martins; Daniela P Lage; Mariana C Duarte; Ana Maria R S Carvalho; Lourena E Costa; Tiago A O Mendes; Danniele L Vale; Daniel Menezes-Souza; Bruno M Roatt; Carlos A P Tavares; Manuel Soto; Eduardo A F Coelho
Journal:  Cell Immunol       Date:  2016-12-28       Impact factor: 4.868

Review 3.  Leishmaniasis.

Authors:  Sakib Burza; Simon L Croft; Marleen Boelaert
Journal:  Lancet       Date:  2018-08-17       Impact factor: 79.321

Review 4.  Leishmaniases of the New World: current concepts and implications for future research.

Authors:  G Grimaldi; R B Tesh
Journal:  Clin Microbiol Rev       Date:  1993-07       Impact factor: 26.132

5.  Leishmaniasis worldwide and global estimates of its incidence.

Authors:  Jorge Alvar; Iván D Vélez; Caryn Bern; Mercé Herrero; Philippe Desjeux; Jorge Cano; Jean Jannin; Margriet den Boer
Journal:  PLoS One       Date:  2012-05-31       Impact factor: 3.240

6.  Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins.

Authors:  Maria Agallou; Evita Athanasiou; Olga Koutsoni; Eleni Dotsika; Evdokia Karagouni
Journal:  Front Immunol       Date:  2014-06-10       Impact factor: 7.561

7.  Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T-Cell Responsiveness against Visceral Leishmaniasis.

Authors:  Manas Ranjan Dikhit; Akhilesh Kumar; Sushmita Das; Budheswar Dehury; Ajaya Kumar Rout; Fauzia Jamal; Ganesh Chandra Sahoo; Roshan Kamal Topno; Krishna Pandey; V N R Das; Sanjiva Bimal; Pradeep Das
Journal:  Front Immunol       Date:  2017-12-14       Impact factor: 7.561

Review 8.  Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.

Authors:  Marek Wieczorek; Esam T Abualrous; Jana Sticht; Miguel Álvaro-Benito; Sebastian Stolzenberg; Frank Noé; Christian Freund
Journal:  Front Immunol       Date:  2017-03-17       Impact factor: 7.561

9.  Immunogenicity and Protective Efficacy of T-Cell Epitopes Derived From Potential Th1 Stimulatory Proteins of Leishmania (Leishmania) donovani.

Authors:  Sumit Joshi; Narendra Kumar Yadav; Keerti Rawat; Vikash Kumar; Rafat Ali; Amogh Anant Sahasrabuddhe; Mohammad Imran Siddiqi; Wahajul Haq; Shyam Sundar; Anuradha Dube
Journal:  Front Immunol       Date:  2019-02-28       Impact factor: 7.561

Review 10.  Regulation of immunity during visceral Leishmania infection.

Authors:  Vasco Rodrigues; Anabela Cordeiro-da-Silva; Mireille Laforge; Ricardo Silvestre; Jérôme Estaquier
Journal:  Parasit Vectors       Date:  2016-03-01       Impact factor: 3.876
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