Keyou Duan1,2, Jianzhong Guan1,2. 1. Department of Orthopaedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233000, P.R.China. 2. Key Laboratory of Anhui Province for Tissue Transplantation, Bengbu Anhui, 233000, P.R.China.
Abstract
OBJECTIVE: To review the research progress of exosomes (EXOs) derived from different cells in the treatment of osteoporosis (OP). METHODS: Recent relevant literature about EXOs for OP therapy was extensively reviewed. And the related mechanism and clinical application prospect of EXOs derived from different cells in OP therapy were summarized and analyzed. RESULTS: EXOs derived from various cells, including bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, osteocytes, and endothelial cells, et al, can participate in many links in the process of bone remodeling, and their mechanisms involve the regulation of proliferation and differentiation of bone-related cells, the promotion of vascular regeneration and immune regulation, and the suppression of inflammatory reactions. A variety of bioactive substances contained in EXOs are the basis of regulating the process of bone remodeling, and the combination of genetic engineering technology and EXOs-based drug delivery can further improve the therapeutic effect of OP. CONCLUSION: EXOs derived from different cells have great therapeutic effects on OP, and have the advantages of low immunogenicity, high stability, strong targeting ability, and easy storage. EXOs has broad clinical application prospects and is expected to become a new strategy for OP treatment.
OBJECTIVE: To review the research progress of exosomes (EXOs) derived from different cells in the treatment of osteoporosis (OP). METHODS: Recent relevant literature about EXOs for OP therapy was extensively reviewed. And the related mechanism and clinical application prospect of EXOs derived from different cells in OP therapy were summarized and analyzed. RESULTS: EXOs derived from various cells, including bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, osteocytes, and endothelial cells, et al, can participate in many links in the process of bone remodeling, and their mechanisms involve the regulation of proliferation and differentiation of bone-related cells, the promotion of vascular regeneration and immune regulation, and the suppression of inflammatory reactions. A variety of bioactive substances contained in EXOs are the basis of regulating the process of bone remodeling, and the combination of genetic engineering technology and EXOs-based drug delivery can further improve the therapeutic effect of OP. CONCLUSION: EXOs derived from different cells have great therapeutic effects on OP, and have the advantages of low immunogenicity, high stability, strong targeting ability, and easy storage. EXOs has broad clinical application prospects and is expected to become a new strategy for OP treatment.
Entities:
Keywords:
Exosome; bone marrow mesenchymal stem cells; bone remodeling; endothelial cells; osteoblasts; osteoclasts; osteocytes; osteoporosis
Authors: Fanghong Li; Hoyeon Chung; Sakamuri V Reddy; Ganwei Lu; Noriyoshi Kurihara; Allan Z Zhao; G David Roodman Journal: J Bone Miner Res Date: 2005-02-14 Impact factor: 6.741