Literature DB >> 3491182

Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration.

N D Volkow, J D Brodie, A P Wolf, B Angrist, J Russell, R Cancro.   

Abstract

Positron emission tomography (PET) with 11C-2-deoxyglucose (11DG) was used to compare regional brain metabolism in four patients with chronic schizophrenia who had no history of psychotropic medication and in 12 normal controls. Patients had a second PET scan after an injection of thiothixene to evaluate the effects of acute neuroleptics on glucose metabolism. The patients showed higher glucose metabolic values than the normals and did not show the metabolic hypofrontality reported in chronic medicated patients with schizophrenia. Administration of the neuroleptic did not have a significant effect in the metabolic pattern of the patients. These results give support to the hypothesis that prolonged medication may contribute to the metabolic hypofrontal pattern seen in patients with schizophrenia.

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Year:  1986        PMID： 3491182      PMCID： PMC1029057          DOI： 10.1136/jnnp.49.10.1199

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  11 in total

1.  Perceptual capacity, functions of the corpus striatum and schizophrenia.

Authors:  F A METTLER
Journal:  Psychiatr Q       Date:  1955

2.  Intercorrelations of glucose metabolic rates between brain regions: application to healthy males in a state of reduced sensory input.

Authors:  B Horwitz; R Duara; S I Rapoport
Journal:  J Cereb Blood Flow Metab       Date:  1984-12       Impact factor: 6.200

3.  Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study.

Authors:  T Farkas; A P Wolf; J Jaeger; J D Brodie; D R Christman; J S Fowler
Journal:  Arch Gen Psychiatry       Date:  1984-03

4.  Distribution of effects of haloperidol on energy metabolism in the rat brain.

Authors:  J McCulloch; H E Savaki; L Sokoloff
Journal:  Brain Res       Date:  1982-07-08       Impact factor: 3.252

5.  Quantitation in positron emission computed tomography: 5. Physical--anatomical effects.

Authors:  J C Mazziotta; M E Phelps; D Plummer; D E Kuhl
Journal:  J Comput Assist Tomogr       Date:  1981-10       Impact factor: 1.826

6.  Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia.

Authors:  M S Buchsbaum; D H Ingvar; R Kessler; R N Waters; J Cappelletti; D P van Kammen; A C King; J L Johnson; R G Manning; R W Flynn; L S Mann; W E Bunney; L Sokoloff
Journal:  Arch Gen Psychiatry       Date:  1982-03

7.  Use of 2-deoxy-D[1-11C]glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects.

Authors:  M Reivich; A Alavi; A Wolf; J H Greenberg; J Fowler; D Christman; R MacGregor; S C Jones; J London; C Shiue; Y Yonekura
Journal:  J Cereb Blood Flow Metab       Date:  1982-09       Impact factor: 6.200

8.  Haloperidol and cerebral metabolism in the conscious rat: relation to pharmacokinetics.

Authors:  G Pizzolato; T T Soncrant; S I Rapoport
Journal:  J Neurochem       Date:  1984-09       Impact factor: 5.372

9.  Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography.

Authors:  A Wolkin; J Jaeger; J D Brodie; A P Wolf; J Fowler; J Rotrosen; F Gomez-Mont; R Cancro
Journal:  Am J Psychiatry       Date:  1985-05       Impact factor: 18.112

10.  PET studies of glucose metabolism in patients with schizophrenia.

Authors:  L Widen; G Blomqvist; T Greitz; J E Litton; M Bergström; E Ehrin; K Ericson; L Eriksson; D H Ingvar; L Johansson; J L Nilsson; S Stone-Elander; G Sedvall; F Wiesel; G Wiik
Journal:  AJNR Am J Neuroradiol       Date:  1983 May-Jun       Impact factor: 3.825
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  12 in total

Review 1.  Functional brain mapping of psychopathology.

Authors:  G D Honey; P C Fletcher; E T Bullmore
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-04       Impact factor: 10.154

Review 2.  Exploring Metabolism In Vivo Using Endogenous 11C Metabolic Tracers.

Authors:  Kiel Neumann; Robert Flavell; David M Wilson
Journal:  Semin Nucl Med       Date:  2017-07-11       Impact factor: 4.446

3.  Hypermetabolic pattern in frontal cortex and other brain regions in unmedicated schizophrenia patients. Results from a FDG-PET study.

Authors:  M Soyka; W Koch; H J Möller; T Rüther; K Tatsch
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2005-04-18       Impact factor: 5.270

4.  Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and 11C-raclopride.

Authors:  C J Bench; A A Lammertsma; R J Dolan; P M Grasby; S J Warrington; K Gunn; M Cuddigan; D J Turton; S Osman; R S Frackowiak
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

5.  Antagonism at serotonin 5-HT(2A) receptors modulates functional activity of frontohippocampal circuit.

Authors:  Alessandro Gozzi; Valerio Crestan; Giuliano Turrini; Marcel Clemens; Angelo Bifone
Journal:  Psychopharmacology (Berl)       Date:  2010-01-29       Impact factor: 4.530

6.  Presynaptic Dopamine Synthesis Capacity in Schizophrenia and Striatal Blood Flow Change During Antipsychotic Treatment and Medication-Free Conditions.

Authors:  Daniel Paul Eisenberg; Lisa Yankowitz; Angela M Ianni; Dani Y Rubinstein; Philip D Kohn; Catherine E Hegarty; Michael D Gregory; José A Apud; Karen F Berman
Journal:  Neuropsychopharmacology       Date:  2017-04-07       Impact factor: 7.853

7.  Effects of ketamine on prefrontal and striatal regions in an overt verbal fluency task: a functional magnetic resonance imaging study.

Authors:  Cynthia H Y Fu; Kathryn M Abel; Matthew P G Allin; David Gasston; Sergi G Costafreda; John Suckling; Steve C R Williams; Philip K McGuire
Journal:  Psychopharmacology (Berl)       Date:  2005-10-22       Impact factor: 4.530

8.  Left globus pallidus abnormality in never-medicated patients with schizophrenia.

Authors:  T S Early; E M Reiman; M E Raichle; E L Spitznagel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

9.  Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography.

Authors:  G Wik; F A Wiesel; I Sjögren; G Blomqvist; T Greitz; S Stone-Elander
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

10.  Hypofrontality revisited: a high resolution single photon emission computed tomography study in schizophrenia.

Authors:  K P Ebmeier; S M Lawrie; D H Blackwood; E C Johnstone; G M Goodwin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-04       Impact factor: 10.154
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