Literature DB >> 3491177

Paucity of phosphorylcholine-specific clones in B cells expressing the VHT15 gene product.

D Primi, E Barbier, A M Drapier, P A Cazenave.   

Abstract

The aim of this work was to study the cellular basis of the phenomenon of clonal dominance. To this end we analyzed two collections of BALB/c and C.B20 hybridomas that we selected on the basis of the expression of the VHT15 gene product independently from their antigen specificity. Our study demonstrates that none of the 28 BALB/c and only 2 of the 29 C.B20 hybridomas obtained have variable regions that bind PC. We conclude therefore that the domination of the immune response to PC by particular variable regions cannot be due to the establishment of clonal dominance prior to immunization.

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Year:  1986        PMID： 3491177      PMCID： PMC2188473          DOI： 10.1084/jem.164.6.2107

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  14 in total

1.  Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

Authors:  K J Nelson; J Haimovich; R P Perry
Journal:  Mol Cell Biol       Date:  1983-07       Impact factor: 4.272

2.  A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

Authors:  S Crews; J Griffin; H Huang; K Calame; L Hood
Journal:  Cell       Date:  1981-07       Impact factor: 41.582

3.  Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.

Authors:  A L Bothwell; M Paskind; M Reth; T Imanishi-Kari; K Rajewsky; D Baltimore
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

4.  Monoclonal antibodies coupled to LPS specifically induce synthesis of immunoglobulins with complementary variable region determinants.

Authors:  D Primi; P A Cazenave
Journal:  J Immunol       Date:  1982-09       Impact factor: 5.422

5.  Selective and polyclonal induction of high levels of lambda light chain-bearing immunoglobulins in BALB/c and SJL mice.

Authors:  D Primi; P Sanchez; P A Cazenave
Journal:  Eur J Immunol       Date:  1984-12       Impact factor: 5.532

6.  Complete sharing of light chain spectrotypes by murine IgM and IgG anti-streptococcal antibodies.

Authors:  R M Perlmutter; D E Briles; J M Davie
Journal:  J Immunol       Date:  1977-06       Impact factor: 5.422

7.  Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine.

Authors:  P Barstad; S Rudikoff; M Potter; M Cohn; W Konigsberg; L Hood
Journal:  Science       Date:  1974-03-08       Impact factor: 47.728

8.  Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice.

Authors:  J F Kearney; R Barletta; Z S Quan; J Quintáns
Journal:  Eur J Immunol       Date:  1981-11       Impact factor: 5.532

9.  Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.

Authors:  C Schiff; M Milili; M Fougereau
Journal:  Nucleic Acids Res       Date:  1983-06-25       Impact factor: 16.971

10.  Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire.

Authors:  N R Klinman; M R Stone
Journal:  J Exp Med       Date:  1983-12-01       Impact factor: 14.307
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  2 in total

1.  Biological mimicry of antigenic stimulation: analysis of the in vivo antibody responses induced by monoclonal anti-idiotypic antibodies.

Authors:  J Y Huang; R E Ward; H Kohler
Journal:  Immunology       Date:  1988-01       Impact factor: 7.397

2.  Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.

Authors:  N C Chien; R R Pollock; C Desaymard; M D Scharff
Journal:  J Exp Med       Date:  1988-03-01       Impact factor: 14.307
  2 in total

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