Literature DB >> 3491144

Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.

P W Gray, D Glaister, E Chen, D V Goeddel, D Pennica.   

Abstract

A human interleukin 1 beta (IL 1 beta) cDNA probe was utilized to identify a homologous murine cDNA clone. The murine cDNA encodes a 269-residue protein which is 67% homologous to human IL 1 beta. The murine sequence was engineered for expression in mammalian cells and directs the synthesis of biologically active IL 1. This protein, termed murine IL 1 beta, is only 22% homologous with the previously described murine IL 1 sequence. Both IL 1 alpha and IL 1 beta are encoded by single genes, but IL 1 beta mRNA is about fivefold more abundant in a stimulated macrophage cell line.

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Year:  1986        PMID： 3491144

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  49 in total

1.  Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma.

Authors:  M Rostworowski; V Balasingam; S Chabot; T Owens; V W Yong
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

2.  Colonic muscle enhances the production of interleukin-1 beta messenger RNA in experimental colitis.

Authors:  I Khan; F M al-Awadi
Journal:  Gut       Date:  1997-03       Impact factor: 23.059

Review 3.  Ovarian hyperstimulation syndrome: a review of pathophysiology.

Authors:  P A Bergh; D Navot
Journal:  J Assist Reprod Genet       Date:  1992-10       Impact factor: 3.412

4.  Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis.

Authors:  S A McDonald; M J Palmen; E P Van Rees; T T MacDonald
Journal:  Immunology       Date:  1997-05       Impact factor: 7.397

5.  Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.

Authors:  C Berkowitz; Y Becker
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

6.  Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription.

Authors:  D R Robinson; M Urakaze; R Huang; H Taki; E Sugiyama; C T Knoell; L Xu; E T Yeh; P E Auron
Journal:  Lipids       Date:  1996-03       Impact factor: 1.880

7.  Interleukin-1 alpha gene-transcription in murine keratinocytes is inhibited by HSV-1 infection.

Authors:  C Enk; E Sprecher; Y Becker
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

8.  Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

Authors:  R C Fuhlbrigge; S M Fine; E R Unanue; D D Chaplin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

9.  The role of SRC kinase in the caspase-1 pathway after hypoxia in the brain of newborn piglets.

Authors:  Dimitrios Angelis; Tania D Fontánez-Nieves; Maria Delivoria-Papadopoulos
Journal:  Neurochem Res       Date:  2014-08-06       Impact factor: 3.996

10.  IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P-component (SAP).

Authors:  B F Lin; N O Ku; K Zahedi; A S Whitehead; R F Mortensen
Journal:  Inflammation       Date:  1990-06       Impact factor: 4.092
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