Literature DB >> 3491051

Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice.

W Solbach, K Forberg, M Röllinghoff.   

Abstract

Treatment of Leishmania major-infected, genetically susceptible BALB/c mice with the T-lymphocyte-immunosuppressive drug cyclosporin A (CyA) resulted in a significantly reduced parasite burden in the local site of infection and in the draining lymph nodes. These data indicate that T cells are pivotal for the propagation of L. major in vivo.

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Year:  1986        PMID： 3491051      PMCID： PMC260260          DOI： 10.1128/iai.54.3.909-912.1986

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

Review 1.  The role of cell-mediated immunity in bacterial infections.

Authors:  H Hahn; S H Kaufmann
Journal:  Rev Infect Dis       Date:  1981 Nov-Dec

2.  Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

Authors:  C Taswell
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

3.  Prophylactic immunization against experimental leishmaniasis: I. Protection induced in mice genetically vulnerable to fatal Leishmania tropica infection.

Authors:  J G Howard; S Nicklin; C Hale; F Y Liew
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

4.  Cyclosporin A inhibits the delayed-type hypersensitivity reaction: impaired production of early pro-inflammatory mediator(s).

Authors:  B Shidani; G Milon; G Marchal; P Truffa-Bachi
Journal:  Eur J Immunol       Date:  1984-04       Impact factor: 5.532

5.  Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.

Authors:  H W Murray; B Y Rubin; C D Rothermel
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

6.  Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.

Authors:  A W Thomson; D K Moon; C L Geczy; D S Nelson
Journal:  Immunology       Date:  1983-02       Impact factor: 7.397

7.  Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro.

Authors:  S P Nickell; L W Scheibel; G A Cole
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

8.  Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T cell populations capable of mediating Leishmania major-specific delayed-type hypersensitivity.

Authors:  R G Titus; G C Lima; H D Engers; J A Louis
Journal:  J Immunol       Date:  1984-09       Impact factor: 5.422

9.  Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.

Authors:  D Bunjes; C Hardt; M Röllinghoff; H Wagner
Journal:  Eur J Immunol       Date:  1981-08       Impact factor: 5.532

10.  Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.

Authors:  J G Howard; C Hale; F Y Liew
Journal:  J Exp Med       Date:  1980-09-01       Impact factor: 14.307
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  15 in total

1.  Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.

Authors:  Sabine Leitherer; Joachim Clos; Elisabeth M Liebler-Tenorio; Ulrike Schleicher; Christian Bogdan; Didier Soulat
Journal:  Infect Immun       Date:  2017-07-19       Impact factor: 3.441

2.  Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis.

Authors:  M Lohoff; C Matzner; M Röllinghoff
Journal:  Infect Immun       Date:  1988-08       Impact factor: 3.441

3.  Cyclosporin A enhances elimination of intracellular L. major parasites by murine macrophages.

Authors:  C Bogdan; H Streck; M Röllinghoff; W Solbach
Journal:  Clin Exp Immunol       Date:  1989-01       Impact factor: 4.330

4.  Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.

Authors:  C Rascher; A Pahl; A Pecht; K Brune; W Solbach; H Bang
Journal:  Biochem J       Date:  1998-09-15       Impact factor: 3.857

5.  Stimulation of B-cell lymphopoiesis by interleukin-7 leads to aggravation of murine leishmaniasis.

Authors:  A Gessner; A Will; M Vieth; K Schröppel; M Röllinghoff
Journal:  Immunology       Date:  1995-03       Impact factor: 7.397

6.  Cloning and characterization of Giardia intestinalis cyclophilin.

Authors:  Hak-Sun Yu; Hyun-Hee Kong; Dong-Il Chung
Journal:  Korean J Parasitol       Date:  2002-09       Impact factor: 1.341

7.  Interleukin-7 enhances antimicrobial activity against Leishmania major in murine macrophages.

Authors:  A Gessner; M Vieth; A Will; K Schröppel; M Röllinghoff
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

8.  Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis.

Authors:  A Gessner; K Schröppel; A Will; K H Enssle; L Lauffer; M Röllinghoff
Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441

9.  Kinetics of cell-mediated immunity developing during the course of Leishmania major infection in 'healer' and 'non-healer' mice: progressive impairment of response to and generation of interleukin-2.

Authors:  W Solbach; M Lohoff; H Streck; P Rohwer; M Röllinghoff
Journal:  Immunology       Date:  1987-11       Impact factor: 7.397

10.  Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major.

Authors:  S Stenger; H Thüring; M Röllinghoff; C Bogdan
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307
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