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Literature DB >> 3491049

Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae.

T F Murphy, L C Bartos, A A Campagnari, M B Nelson, M A Apicella.

Abstract

The purpose of this study was to characterize the degree of antigenic heterogeneity or conservation of a 16,600-dalton outer membrane protein (P6) among strains of nontypable Haemophilus influenzae. Immunization of rabbits with P6 isolated from individual strains resulted in antibody to P6 of all 25 strains tested. The titers of antibody in the sera were similar among the strains. Whole organisms of two strains were used to immunize rabbits, and antibodies were produced to P6 of all strains tested. Monoclonal antibodies developed to P6 from mice immunized with whole cells of three different strains recognized determinants on P6 of all 25 strains tested. Finally, pooled normal human serum contained antibodies to P6 of all 25 strains assayed. These studies indicate that P6 is a highly conserved antigen on the outer membrane of nontypable H. influenzae.

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Year: 1986 PMID： 3491049 PMCID： PMC260236 DOI： 10.1128/iai.54.3.774-779.1986

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

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Authors: E B Myhre
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Journal: J Infect Dis Date: 1981-08 Impact factor: 5.226

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Journal: J Infect Dis Date: 1981-05 Impact factor: 5.226

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Journal: Infect Immun Date: 1980-12 Impact factor: 3.441

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Authors: J O Klein
Journal: Ann Otol Rhinol Laryngol Suppl Date: 1981 May-Jun

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Authors: T F Murphy; K C Dudas; J M Mylotte; M A Apicella
Journal: J Infect Dis Date: 1983-05 Impact factor: 5.226

Review 10. Haemophilus influenzae meningitis: the spectrum of disease in adults.

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Journal: Medicine (Baltimore) Date: 1982-03 Impact factor: 1.889

46 in total

1. Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains.

Authors: J M Neary; K Yi; R J Karalus; T F Murphy
Journal: Infect Immun Date: 2001-02 Impact factor: 3.441

2. Neonatal, urogenital isolates of biotype 4 nontypeable Haemophilus influenzae express a variant P6 outer membrane protein molecule.

Authors: T F Murphy; C Kirkham; D J Sikkema
Journal: Infect Immun Date: 1992-05 Impact factor: 3.441

Review 3. Molecular biology and respiratory disease. 6. Modern molecular biology and respiratory bacterial infections: a revolution on the horizon.

Authors: T F Murphy
Journal: Thorax Date: 1990-07 Impact factor: 9.139

4. Cloning of genes encoding a 15,000-dalton peptidoglycan-associated outer membrane lipoprotein and an antigenically related 15,000-dalton protein from Haemophilus influenzae.

Authors: R A Deich; B J Metcalf; C W Finn; J E Farley; B A Green
Journal: J Bacteriol Date: 1988-02 Impact factor: 3.490

5. Antigenic conservation of the 15,000-dalton outer membrane lipoprotein PCP of Haemophilus influenzae and biologic activity of anti-PCP antisera.

Authors: R A Deich; A Anilionis; J Fulginiti; B J Metcalf; S Quataert; T Quinn-Dey; G W Zlotnick; B A Green
Journal: Infect Immun Date: 1990-10 Impact factor: 3.441

6. Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis.

Authors: T F Murphy; C Kirkham; E DeNardin; S Sethi
Journal: Infect Immun Date: 1999-09 Impact factor: 3.441

7. Antigenic characterization of the oligosaccharide portion of the lipooligosaccharide of nontypable Haemophilus influenzae.

Authors: C C Patrick; A Kimura; M A Jackson; L Hermanstorfer; A Hood; G H McCracken; E J Hansen
Journal: Infect Immun Date: 1987-12 Impact factor: 3.441

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Journal: Infect Immun Date: 1988-10 Impact factor: 3.441

9. Mapping of a surface-exposed, conformational epitope of the P6 protein of Haemophilus influenzae.

Authors: J A Bogdan; M A Apicella
Journal: Infect Immun Date: 1995-11 Impact factor: 3.441

10. Conservation of immune responses to proteins isolated by preparative polyacrylamide gel electrophoresis from the outer membrane of nontypeable Haemophilus influenzae.

Authors: J M Kyd; D Taylor; A W Cripps
Journal: Infect Immun Date: 1994-12 Impact factor: 3.441