| Literature DB >> 3490673 |
F Bussolino, F Breviario, C Tetta, M Aglietta, F Sanavio, A Mantovani, E Dejana.
Abstract
Monocyte-derived interleukin 1 (IL 1) induced the platelet activating factor (PAF) production in cultured human endothelial cells (HEC). The product was identified as PAF by the chemical properties, the susceptibility to phospholipase A2 and C and to lipase A1, its behaviour in thin layer chromatography and in high pressure liquid chromatography and the recovery of biological activity tested on rabbit platelets. The action of IL 1 was concentration-dependent and took more than 2 hours to became apparent. Most of the PAF produced was cell-associated and only the 25% of the total was released.Entities:
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Year: 1986 PMID： 3490673 DOI： 10.1016/0031-6989(86)90046-9
Source DB: PubMed Journal: Pharmacol Res Commun ISSN： 0031-6989