Literature DB >> 34906316

Using epigenetic modifiers to target cancer stem cell immunoevasion.

Claudia Galassi1, Ilio Vitale2, Lorenzo Galluzzi3.   

Abstract

Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  KDM5B; MAVS; STING1; endogenous retroviruses; immune checkpoint inhibitors; type I IFN

Mesh：

Year:  2021        PMID： 34906316     DOI： 10.1016/j.ccell.2021.11.003

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  4 in total

Review 1.  Targeting Cancer Stem Cells through Epigenetic Modulation of Interferon Response.

Authors:  Jau-Ling Huang; Si-Yun Chen; Chang-Shen Lin
Journal:  J Pers Med       Date:  2022-04-01

Review 2.  Identification, Culture and Targeting of Cancer Stem Cells.

Authors:  Alejandro Herreros-Pomares
Journal:  Life (Basel)       Date:  2022-01-27

Review 3.  Mechanisms of Immunotherapy Resistance in Cutaneous Melanoma: Recognizing a Shapeshifter.

Authors:  Jessica Thornton; Gagan Chhabra; Chandra K Singh; Glorimar Guzmán-Pérez; Carl A Shirley; Nihal Ahmad
Journal:  Front Oncol       Date:  2022-04-19       Impact factor: 5.738

4.  m7G-Related DNA Damage Repair Genes are Potential Biomarkers for Predicting Prognosis and Immunotherapy Effectiveness in Colon Cancer Patients.

Authors:  Shuran Chen; Rui Dong; Yan Li; Ni Zheng; Guisen Peng; Fei Lu; Quanwei Qiu; Hexin Wen; Yitong Wang; Huazhang Wu; Mulin Liu
Journal:  Front Genet       Date:  2022-06-09       Impact factor: 4.772
  4 in total

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