Literature DB >> 3490631

Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393.

M Mashurano, J L Waddington.   

Abstract

When given alone, 2.5 mg/kg of the selective D-2 agonist RU 24213 was a threshold dose for the induction of weak stereotyped behaviour, while 15 mg/kg of the selective D-1 agonist SK&F 38393 failed to induce stereotypy. Responses to 2.5 mg/kg RU 24213 were dose-dependently potentiated by 3.0-15.0 mg/kg SK&F 38393, and compulsive stereotypy was only evident in animals receiving the combination treatment. Increasing D-1 dopaminergic activity appears to promote the expression of behaviours initiated through D-2 receptor stimulation.

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Year:  1986        PMID： 3490631     DOI： 10.1016/0028-3908(86)90027-4

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  31 in total

1.  Ontogenetic differences in the psychopharmacological responses to separate and combined stimulation of D1 and D2 dopamine receptors during the neonatal to weanling age period.

Authors:  C A Moody; L P Spear
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets.

Authors:  P A Löschmann; L A Smith; K W Lange; P Jähnig; P Jenner; C D Marsden
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Dopaminergic control of locomotion, mouthing, snout contact, and grooming: opposing roles of D1 and D2 receptors.

Authors:  D Eilam; H Talangbayan; G Canaran; H Szechtman
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

4.  Behavioural responses to the selective D1-dopamine receptor agonist R-SK&F 38393 and the selective D2-agonist RU 24213 in young compared with aged rats.

Authors:  A G Molloy; J L Waddington
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

5.  Changes in behavioural responses to the combined administration of D1 and D2 dopamine agonists in normosensitive and D1 supersensitive rats.

Authors:  R Dall'Olio; O Gandolfi; A Vaccheri; P Roncada; N Montanaro
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

6.  SKF 38393 potentiates yawning induced by LY 171555: further evidence against the autoreceptor hypothesis of yawning.

Authors:  L Spina; R Longoni; A Mulas; G Di Chiara
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  Dopamine D-2 receptor agonist-induced behavioural depression: critical dependence upon postsynaptic dopamine D-1 function. A behavioural and biochemical study.

Authors:  D M Jackson; S B Ross; L G Larsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

8.  Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors.

Authors:  S A McDougall; C A Crawford; A J Nonneman
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidal syndromes and dopaminergic supersensitivity.

Authors:  H Lublin; J Gerlach; L Peacock
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

10.  Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups.

Authors:  C A Moody; L P Spear
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
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