| Literature DB >> 34905377 |
Zhen Chen1,2, Ahmed Haider1,2, Jiahui Chen1, Zhiwei Xiao1,2, Luca Gobbi3, Michael Honer3, Uwe Grether3, Steven E Arnold4, Lee Josephson1,2, Steven H Liang1,2.
Abstract
Neuroinflammation is an adaptive response of the central nervous system to diverse potentially injurious stimuli, which is closely associated with neurodegeneration and typically characterized by activation of microglia and astrocytes. As a noninvasive and translational molecular imaging tool, positron emission tomography (PET) could provide a better understanding of neuroinflammation and its role in neurodegenerative diseases. Ligands to translator protein (TSPO), a putative marker of neuroinflammation, have been the most commonly studied in this context, but they suffer from serious limitations. Herein we present a repertoire of different structural chemotypes and novel PET ligand design for classical and emerging neuroinflammatory targets beyond TSPO. We believe that this Perspective will support multidisciplinary collaborations in academic and industrial institutions working on neuroinflammation and facilitate the progress of neuroinflammation PET probe development for clinical use.Entities:
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Year: 2021 PMID： 34905377 PMCID： PMC9094091 DOI： 10.1021/acs.jmedchem.1c01571
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 8.039