Literature DB >> 34904258

Utilization and evolving prescribing practice of opioid and non-opioid analgesics in patients undergoing lymphadenectomy for cutaneous malignancy.

Russell G Witt1, Brandon Cope1, Yi-Ju Chiang1, Timothy Newhook1, Heather Lillemoe1, Ching-Wei D Tzeng1, Iris B Chen1, Sarah B Fisher1, Anthony Lucci1, Jennifer A Wargo1, Jeffrey E Lee1, Merrick I Ross1, Jeffrey E Gershenwald1, Justine Robinson1, Emily Z Keung1.   

Abstract

BACKGROUND AND OBJECTIVES: Opioids are commonly prescribed following surgery and can lead to persistent opioid use. We assessed changes in prescribing practices following an opioid education initiative for patients undergoing lymphadenectomy for cutaneous malignancy.
METHODS: A single-institution retrospective study of all eligible patients (3/2016-3/2020) was performed.
RESULTS: Indications for lymphadenectomy in 328 patients were metastatic melanoma (84%), squamous cell carcinoma (10%), and Merkel cell carcinoma (5%). At discharge, non-opioid analgesics were increasingly utilized over the 4-year study period, with dramatic increases after education initiatives (32%, 42%, 59%, and 79% of pts, respectively each year; p < 0.001). Median oral morphine equivalents (OMEs) prescribed also decreased dramatically starting in year 3 (250, 238, 150, and 100 mg, respectively; p < 0.001). Patients discharged with 200 mg OMEs were less likely to also be discharged with non-opioid analgesics (40% vs. 64%. respectively, p < 0.001).
CONCLUSIONS: Analgesic prescribing practices following lymphadenectomy for cutaneous malignancy improved significantly over a 4-year period, with use of non-opioids more than doubling and a 60% reduction in median OME. Opportunities exist to further increase non-opioid use and decrease opioid dissemination after lymphadenectomy for cutaneous malignancy.
© 2021 Wiley Periodicals LLC.

Entities:  

Keywords:  lymphadenectomy; melanoma; narcotics; non-opioid; opioid; postoperative analgesia

Mesh:

Substances:

Year:  2021        PMID: 34904258      PMCID: PMC9108995          DOI: 10.1002/jso.26768

Source DB:  PubMed          Journal:  J Surg Oncol        ISSN: 0022-4790            Impact factor:   2.885


  28 in total

1.  Treatment of Acute Renal Colic in US and French EDs: Simulated Cases and Real Cases in Acute Pain Management.

Authors:  Vincent Bounes; Baptiste Vallé; François Concina; Dominique Lauque; Jean-Louis Ducassé; Jonathan A Edlow
Journal:  Am J Emerg Med       Date:  2016-07-04       Impact factor: 2.469

2.  Clinical Factors Associated With Practice Variation in Discharge Opioid Prescriptions After Pancreatectomy.

Authors:  Timothy E Newhook; Timothy J Vreeland; Whitney L Dewhurst; Xuemei Wang; Laura Prakash; Chun Feng; Morgan L Bruno; Michael P Kim; Thomas A Aloia; Jean-Nicolas Vauthey; Jeffrey E Lee; Matthew H G Katz; Ching-Wei D Tzeng
Journal:  Ann Surg       Date:  2020-07       Impact factor: 12.969

3.  Comparison of Opioid Utilization Patterns After Major Head and Neck Procedures Between Hong Kong and the United States.

Authors:  Ryan J Li; Myriam Loyo Li; Enrique Leon; Cherrie W K Ng; Maisie Shindo; Katie Manzione; Peter Andersen; Daniel Clayburgh; Mark Wax; Jason Y K Chan
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2018-11-01       Impact factor: 6.223

4.  Risks of Developing Persistent Opioid Use After Major Surgery.

Authors:  Neilesh Soneji; Hance A Clarke; Dennis T Ko; Duminda N Wijeysundera
Journal:  JAMA Surg       Date:  2016-11-01       Impact factor: 14.766

5.  Enhanced recovery in liver surgery decreases postoperative outpatient use of opioids.

Authors:  Heather A Lillemoe; Rebecca K Marcus; Ryan W Day; Bradford J Kim; Nisha Narula; Catherine H Davis; Vijaya Gottumukkala; Thomas A Aloia
Journal:  Surgery       Date:  2019-05-15       Impact factor: 3.982

6.  Educating surgical oncology providers on perioperative opioid use: A departmental survey 1 year after the intervention.

Authors:  Bradford J Kim; Heather A Lillemoe; Timothy E Newhook; Whitney L Dewhurst; Elsa M Arvide; Matthew H G Katz; Thomas A Aloia; Jean-Nicolas Vauthey; Jeffrey E Lee; Ching-Wei D Tzeng
Journal:  J Surg Oncol       Date:  2020-05-23       Impact factor: 3.454

7.  Patient outcomes and provider perceptions following implementation of a standardized perioperative care pathway for open liver resection.

Authors:  A J Page; F Gani; K T Crowley; K H K Lee; M C Grant; T L Zavadsky; D Hobson; C Wu; E C Wick; T M Pawlik
Journal:  Br J Surg       Date:  2016-02-09       Impact factor: 6.939

8.  New Persistent Opioid Use Among Patients With Cancer After Curative-Intent Surgery.

Authors:  Jay Soong-Jin Lee; Hsou Mei Hu; Anthony L Edelman; Chad M Brummett; Michael J Englesbe; Jennifer F Waljee; Jeffrey B Smerage; Jennifer J Griggs; Hari Nathan; Jacqueline S Jeruss; Lesly A Dossett
Journal:  J Clin Oncol       Date:  2017-10-19       Impact factor: 44.544

9.  Inpatient Opioid Use After Pancreatectomy: Opportunities for Reducing Initial Opioid Exposure in Cancer Surgery Patients.

Authors:  Timothy E Newhook; Whitney L Dewhurst; Timothy J Vreeland; Xuemei Wang; Jose Soliz; B Bryce Speer; Shannon Hancher-Hodges; Chun Feng; Morgan L Bruno; Michael P Kim; Thomas A Aloia; Jean-Nicolas Vauthey; Jeffrey E Lee; Matthew H G Katz; Ching-Wei D Tzeng
Journal:  Ann Surg Oncol       Date:  2019-06-26       Impact factor: 5.344

10.  Rates and risk factors for prolonged opioid use after major surgery: population based cohort study.

Authors:  Hance Clarke; Neilesh Soneji; Dennis T Ko; Lingsong Yun; Duminda N Wijeysundera
Journal:  BMJ       Date:  2014-02-11
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