Literature DB >> 3490373

Radioiodinated free fatty acids; can we measure myocardial metabolism?

F C Visser, M J van Eenige, C M Duwel, J P Roos.   

Abstract

To investigate the feasibility of radioiodinated free fatty acids for 'metabolic imaging', the kinetics and distribution pattern of metabolites of 131I-heptadecanoic acid were studied in canine myocardium throughout metabolic interventions. In control dogs and in dogs during glucose/insulin and sodium lactate infusion, biopsy specimens were taken during a 90-min period after 131I-HDA administration and analyzed. Clearly distinct patterns of distribution and elimination were seen during the metabolic interventions, indicating the usefulness of iodinated fatty acids for metabolic studies.

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Year:  1986        PMID： 3490373     DOI： 10.1007/BF00258097

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  15 in total

1.  Myocardial metabolism of glucose, lactic acid, amino acids and fatty acids in healthy human individuals at rest and at different work loads.

Authors:  A CARLSTEN; B HALLGREN; R JAGENBURG; A SVANBORG; L WERKO
Journal:  Scand J Clin Lab Invest       Date:  1961       Impact factor: 1.713

Review 2.  Myocardial utilization of carbohydrate and lipids.

Authors:  J R Neely; M J Rovetto; J F Oram
Journal:  Prog Cardiovasc Dis       Date:  1972 Nov-Dec       Impact factor: 8.194

3.  Clinical evaluation of 123I-labeled p-phenylpentadecanoic acid (p-IPPA) for myocardial scintigraphy.

Authors:  R Dudczak; R Schmoliner; K Kletter; H Frischauf; P Angelberger
Journal:  J Nucl Med Allied Sci       Date:  1983 Oct-Dec

4.  C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography. III. In vivo demonstration of the effects of substrate availability on myocardial metabolism.

Authors:  H R Schelbert; E Henze; H R Schon; R Keen; H Hansen; C Selin; S C Huang; J R Barrio; M E Phelps
Journal:  Am Heart J       Date:  1983-03       Impact factor: 4.749

5.  The myocardial elimination rate of radioiodinated heptadecanoic acid.

Authors:  F C Visser; G Westera; M J van Eenige; E E Van der Wall; W Den Hollander; J P Roos
Journal:  Eur J Nucl Med       Date:  1985

6.  The elimination rate of 123I-heptadecanoic acid after intracoronary and intravenous administration.

Authors:  F C Visser; M J van Eenige; E E van der Wall; G Westera; C J van Engelen; A van Lingen; C C de Cock; W den Hollander; G A Heidendal; J P Roos
Journal:  Eur J Nucl Med       Date:  1985

7.  Metabolic fate of radioiodinated heptadecanoic acid in the normal canine heart.

Authors:  F C Visser; M J van Eenige; G Westera; W Den Hollander; C M Duwel; E E van der Wall; G A Heidendal; J P Roos
Journal:  Circulation       Date:  1985-09       Impact factor: 29.690

8.  Myocardial scintigraphy with 123I-labelled heptadecanoic acid in patients with unstable angina pectoris.

Authors:  E E van der Wall; G A Heidendal; W den Hollander; G Westera; J P Roos
Journal:  Postgrad Med J       Date:  1983       Impact factor: 2.401

9.  The use of 123I-labeled heptadecanoic acid (HDA) as metabolic tracer: preliminary report.

Authors:  R Dudczak; K Kletter; H Frischauf; U Losert; P Angelberger; R Schmoliner
Journal:  Eur J Nucl Med       Date:  1984

10.  123I-phenylpentadecanoic acid as a tracer of cardiac free fatty acid metabolism. Experimental and clinical results.

Authors:  S N Reske
Journal:  Eur Heart J       Date:  1985-08       Impact factor: 29.983
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  6 in total

1.  Enhanced lipolysis of myocardial triglycerides during low-flow ischemia and anoxia in the isolated rat heart.

Authors:  K Schoonderwoerd; S Broekhoven-Schokker; W C Hülsmann; H Stam
Journal:  Basic Res Cardiol       Date:  1989 Mar-Apr       Impact factor: 17.165

2.  Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemia.

Authors:  M P Hudon; D M Lyster; E W Jamieson; K A Qayumi; M C Kiess; L J Rosado; A P Autor; C Sartori; H Dougan; J van den Broek
Journal:  Eur J Nucl Med       Date:  1988

3.  Beta-oxidation of 1-[14C]-17-[131I]-iodo-heptadecanoic acid following intracoronary injection in humans results in similar release of both tracers.

Authors:  M M Henrich; K Grossmann; W Motz; M Vogt; E Vester; M Holschbach; W Hamkens; G Notohamiprodjo; B E Strauer; L E Feinendegen
Journal:  Eur J Nucl Med       Date:  1993-03

4.  Variables of myocardial backdiffusion, determined with 17-iodo-131 heptadecanoic acid in the normal dog heart.

Authors:  C M Duwel; F C Visser; M J van Eenige; J P Roos
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

Review 5.  Interrelationship between lactate and cardiac fatty acid metabolism.

Authors:  G J van der Vusse; M J de Groot
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396

6.  Incorporation of radioiodinated fatty acids into cardiac phospholipids of normoxic canine myocardium.

Authors:  G W Sloof; F C Visser; T Teerlink; E F Comans; M J Eenige van; G J van der Vusse; F F Knapp
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396
  6 in total

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