Literature DB >> 34902148

Development and Application of DropletProbe Mass Spectrometry for Examining Biodistribution of Therapeutics.

Bingming Chen1, Marissa Vavrek2, Mark T Cancilla2, Vilmos Kertesz3.   

Abstract

dropletProbe mass spectrometry is a novel technique for molecular characterization of surfaces. It can be used for rapid ex vivo analysis of therapeutics from thin animal tissue sections and has been shown to improve understanding of a drug's absorption, distribution, metabolism and excretion (ADME) properties. Here, we describe the tissue distribution analysis of diclofenac from a dosed whole-body mouse thin tissue section using a dropletProbe mass spectrometry system.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Diclofenac; DropletProbe; Mass spectrometry; Metabolite identification; Tissue distribution; Whole-body analysis

Mesh：

Substances：

Year:  2022        PMID： 34902148     DOI： 10.1007/978-1-0716-2030-4_12

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  15 in total

Review 1.  Autoradiography techniques and quantification of drug distribution.

Authors:  Eric G Solon
Journal:  Cell Tissue Res       Date:  2015-01-22       Impact factor: 5.249

Review 2.  MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.

Authors:  Michaela Aichler; Axel Walch
Journal:  Lab Invest       Date:  2015-01-26       Impact factor: 5.662

3.  The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis.

Authors:  Ning Pan; Wei Rao; Naga Rama Kothapalli; Renmeng Liu; Anthony W G Burgett; Zhibo Yang
Journal:  Anal Chem       Date:  2014-09-19       Impact factor: 6.986

4.  Absolute quantitative imaging of sphingolipids in brain tissue by exhaustive liquid microjunction surface sampling-liquid chromatography-mass spectrometry.

Authors:  Qian Wu; Zehui Huang; Yang Wang; Zhimin Zhang; Hongmei Lu
Journal:  J Chromatogr A       Date:  2019-08-07       Impact factor: 4.759

5.  Liquid microjunction surface sampling coupled with high-pressure liquid chromatography-electrospray ionization-mass spectrometry for analysis of drugs and metabolites in whole-body thin tissue sections.

Authors:  Vilmos Kertesz; Gary J Van Berkel
Journal:  Anal Chem       Date:  2010-07-15       Impact factor: 6.986

6.  Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.

Authors:  Daniel Eikel; Marissa Vavrek; Sheri Smith; Carol Bason; Suzie Yeh; Walter A Korfmacher; Jack D Henion
Journal:  Rapid Commun Mass Spectrom       Date:  2011-12-15       Impact factor: 2.419

Review 7.  Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.

Authors:  Jeremy L Norris; Richard M Caprioli
Journal:  Chem Rev       Date:  2013-02-11       Impact factor: 60.622

Review 8.  Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights.

Authors:  Amanda Rae Buchberger; Kellen DeLaney; Jillian Johnson; Lingjun Li
Journal:  Anal Chem       Date:  2017-12-13       Impact factor: 6.986

Review 9.  Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development.

Authors:  Eric G Solon; Alain Schweitzer; Markus Stoeckli; Brendan Prideaux
Journal:  AAPS J       Date:  2009-11-17       Impact factor: 4.009

10.  3D MALDI Mass Spectrometry Imaging of a Single Cell: Spatial Mapping of Lipids in the Embryonic Development of Zebrafish.

Authors:  Maria Emilia Dueñas; Jeffrey J Essner; Young Jin Lee
Journal:  Sci Rep       Date:  2017-11-02       Impact factor: 4.379
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