Effect of interleukin 1 on chemotaxis and chemiluminescence of human neutrophils.

We studied the influence of interleukin 1 (IL 1) on chemotaxis and chemiluminescence (CL) of human neutrophils. We found that IL 1 showed chemotactic activity within the concentrations ranging from 1 to 200 U/ml, whereas no luminol-or lucigenin-dependent CL was noted in neutrophils with the stimulation of IL 1 at the concentrations ranged from 1 to 100 U/ml. Moreover, no enhancement of zymosan-induced CL was observed in neutrophils following prior exposure to IL 1 at a concentration of 100 U/ml for 60 min at 37 degrees C. We think that IL 1 may be responsible for the inflammatory reaction only through its chemotactic activity for neutrophils without enhancement of the oxidative metabolism of neutrophils.