Literature DB >> 34897697

Clinical presentation, treatment, and genetic and histopathological analysis of juvenile cataracts and secondary glaucoma in a rhesus macaque (Macaca mulatta).

M Isabel Casanova1, Rui Chen2,3, Laura M Garzel4, Katherine J Olstad4, Soohyun Kim1, Ronald Alan Harris2, Yumei Li2, Muthuswamy Raveendran2, Qingnan Liang2,3, Jun Wang2, Glenn Yiu5, John Timothy Stout6, Jeffrey A Roberts4,7, Jeffrey Rogers2, Ala Moshiri5, Sara M Thomasy1,4,5.   

Abstract

This report describes the clinical and histological findings, genetic study, and treatment in a 1.3-year-old rhesus macaque with bilateral cataracts and unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased the intraocular pressure from 56 to <2 mm Hg. A putative genetic cause of the cataracts was not identified.
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  chronic glaucoma; intravitreal gentamicin; non-human primate

Mesh：

Year:  2021        PMID： 34897697      PMCID： PMC8897224          DOI： 10.1111/jmp.12560

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


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Journal:  J Med Primatol       Date:  2005-06       Impact factor: 0.667

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Authors:  Kai Wang; Mingyao Li; Hakon Hakonarson
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Authors:  Thobile Ngqaneka; Sanele Khoza; Zandisiwe E Magwebu; Chesa G Chauke
Journal:  J Med Primatol       Date:  2020-01-23       Impact factor: 0.667

Review 8.  Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches.

Authors:  Vanita Berry; Michalis Georgiou; Kaoru Fujinami; Roy Quinlan; Anthony Moore; Michel Michaelides
Journal:  Br J Ophthalmol       Date:  2020-03-25       Impact factor: 4.638

9.  dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions.

Authors:  Xiaoming Liu; Xueqiu Jian; Eric Boerwinkle
Journal:  Hum Mutat       Date:  2011-08       Impact factor: 4.878

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