Poorva Vias1, Shikha Goyal2, Kannan Periasamy1, Renu Madan1, Sudheer Kumar Devana3, Amanjit Bal4, Reetu Kundu5. 1. Department of Radiotherapy, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. 2. Department of Radiotherapy, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. drshikhagoyal@gmail.com. 3. Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. 4. Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. 5. Department of Cytology and Gynaecological Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Abstract
BACKGROUND: Leiomyosarcomas of urinary bladder constitute rare malignant sarcomas with very few cases reported in literature. CASE PRESENTATION: Here, we present a case of bladder leiomyosarcoma in a well-preserved female. She failed to respond to standard chemotherapy and had a rapidly downhill course with unusual metastases in anastomotic site and peritoneum soon after surgery. Despite multimodality management including resection of primary and metastatic site, systemic therapy and pelvic radiotherapy, our patient had dismal prognosis with an overall survival of 1.7 years. CONCLUSION: Leiomyosarcomas of bladder are aggressive tumors and have a very poor prognosis; thus, future research should focus on optimizing more effective treatment regimes.
BACKGROUND: Leiomyosarcomas of urinary bladder constitute rare malignant sarcomas with very few cases reported in literature. CASE PRESENTATION: Here, we present a case of bladder leiomyosarcoma in a well-preserved female. She failed to respond to standard chemotherapy and had a rapidly downhill course with unusual metastases in anastomotic site and peritoneum soon after surgery. Despite multimodality management including resection of primary and metastatic site, systemic therapy and pelvic radiotherapy, our patient had dismal prognosis with an overall survival of 1.7 years. CONCLUSION: Leiomyosarcomas of bladder are aggressive tumors and have a very poor prognosis; thus, future research should focus on optimizing more effective treatment regimes.
Authors: Philippe E Spiess; Wassim Kassouf; Jordan R Steinberg; Tomasz Tuziak; Mike Hernandez; Rita F Tibbs; Bogdan Czerniak; Ashish M Kamat; Colin P N Dinney; H Barton Grossman Journal: Urol Oncol Date: 2007 Jan-Feb Impact factor: 3.498
Authors: Brian C Baumann; Walter R Bosch; Amit Bahl; Alison J Birtle; Rodney H Breau; Amarnath Challapalli; Albert J Chang; Ananya Choudhury; Sia Daneshmand; Ali El-Gayed; Adam Feldman; Steven E Finkelstein; Thomas J Guzzo; Serena Hilman; Ashesh Jani; S Bruce Malkowicz; Constantine A Mantz; Viraj Master; Anita V Mitra; Vedang Murthy; Sima P Porten; Pierre M Richaud; Paul Sargos; Jason A Efstathiou; Libni J Eapen; John P Christodouleas Journal: Int J Radiat Oncol Biol Phys Date: 2016-05-07 Impact factor: 7.038