Literature DB >> 3489714

Uromodulin. An immunosuppressive 85-kilodalton glycoprotein isolated from human pregnancy urine is a high affinity ligand for recombinant interleukin 1 alpha.

A V Muchmore, J M Decker.   

Abstract

Uromodulin is an 85-kDa immunosuppressive glycoprotein originally isolated from human pregnancy urine. It exhibits immunosuppressive activity in vitro at concentrations between 10(-9) and 10(-11) M. Recent data demonstrate that uromodulin is able to specifically inhibit in vitro assays dependent upon interleukin 1 (IL-1). We now present evidence that uromodulin is a high affinity ligand for recombinant murine IL-1 alpha. Since uromodulin has been purified to homogeneity, this should allow extensive further characterization of the mechanism of action of both uromodulin and IL-1.

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Year:  1986        PMID： 3489714

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  Urinary protein electrophoresis profile in normal and hypertensive pregnancies.

Authors:  T Nesselhut; W Rath; G Grospietsch; M H Weber; W Kuhn
Journal:  Arch Gynecol Obstet       Date:  1989       Impact factor: 2.344

Review 2.  Surface proteins and glycoproteins of human leucocytes.

Authors:  V Horejsí; V Bazil
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

3.  Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1. Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171.

Authors:  A E Postlethwaite; G N Smith; L B Lachman; R O Endres; H M Poppleton; K A Hasty; J M Seyer; A H Kang
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

4.  A novel urinary sialoglycoprotein as the inhibitor of interleukin-1.

Authors:  S Kabir; H Wigzell
Journal:  Clin Exp Immunol       Date:  1989-07       Impact factor: 4.330

5.  Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap.

Authors:  Yan Liu; Tarek M El-Achkar; Xue-Ru Wu
Journal:  J Biol Chem       Date:  2012-03-27       Impact factor: 5.157

Review 6.  Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action.

Authors:  R D Nelson; N Shibata; R P Podzorski; M J Herron
Journal:  Clin Microbiol Rev       Date:  1991-01       Impact factor: 26.132

7.  Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1.

Authors:  S J Hopkins; M Humphreys; M I Jayson
Journal:  Clin Exp Immunol       Date:  1988-06       Impact factor: 4.330

8.  Structural identification of an epitope of antigenic factor 5 in mannans of Candida albicans NIH B-792 (serotype B) and J-1012 (serotype A) as beta-1,2-linked oligomannosyl residues.

Authors:  N Shibata; M Arai; E Haga; T Kikuchi; M Najima; T Satoh; H Kobayashi; S Suzuki
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

9.  Tumor necrosis factor in benign and malign tissue of the kidney.

Authors:  K H Bichler; S Kleinknecht; H J Nelde; W L Strohmaier
Journal:  Urol Res       Date:  1991

10.  The interaction of Tamm-Horsfall protein with the extracellular matrix.

Authors:  C Lambert; R Brealey; J Steele; G A Rook
Journal:  Immunology       Date:  1993-06       Impact factor: 7.397
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