Milad Moloudizargari1, Jamal Rahmani2, Mohammad Hossein Asghari3, Ajay Goel1. 1. Department of Molecular Diagnostics & Experimental Therapeutics, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. 2. Department of Community Nutrition, Faculty of Nutrition & Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Department of Pharmacology & Toxicology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Abstract
Aims: To study the association between miR-31 expression and clinical outcomes in colorectal cancer. Methods: A systematic search was performed and 16 studies were found eligible. To calculate the combined hazard ratio (HR), the DerSimonian and Laird random-effects model was used. Results: Pooled analysis revealed significant associations between high miR-31 expression and poor overall (HR: 0.68; 95% CI: 0.47-0.97; I2: 68.6%) and progression-free survival (HR: 0.49; 95% CI: 0.33-0.73; I2: 81.1%). High expressers were more likely to have a BRAF mutation. Therapeutic regimen and the mutational status significantly affected the observed associations. Conclusion: We identified that high miR-31 expression is associated with poor overall survival and progression-free survival and has a significant predictive value for anti-EGFR response.
Aims: To study the association between miR-31 expression and clinical outcomes in colorectal cancer. Methods: A systematic search was performed and 16 studies were found eligible. To calculate the combined hazard ratio (HR), the DerSimonian and Laird random-effects model was used. Results: Pooled analysis revealed significant associations between high miR-31 expression and poor overall (HR: 0.68; 95% CI: 0.47-0.97; I2: 68.6%) and progression-free survival (HR: 0.49; 95% CI: 0.33-0.73; I2: 81.1%). High expressers were more likely to have a BRAF mutation. Therapeutic regimen and the mutational status significantly affected the observed associations. Conclusion: We identified that high miR-31 expression is associated with poor overall survival and progression-free survival and has a significant predictive value for anti-EGFR response.
Authors: Paula Fernández-Palanca; Tania Payo-Serafín; Flavia Fondevila; Carolina Méndez-Blanco; Beatriz San-Miguel; Marta R Romero; María J Tuñón; Jose J G Marin; Javier González-Gallego; José L Mauriz Journal: Cancers (Basel) Date: 2022-07-15 Impact factor: 6.575