Literature DB >> 3489438

Activity of inosine analogs against Pneumocystis carinii in culture.

M S Bartlett, J J Marr, S F Queener, R S Klein, J W Smith.   

Abstract

Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml, and there was some inhibition at 1 microgram/ml. Formycin B was effective only at 40 micrograms/ml. Allopurinol ribonucleoside had little effect.

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Year:  1986        PMID： 3489438      PMCID： PMC176462          DOI： 10.1128/AAC.30.1.181

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  A NEW ANTIBIOTIC, FORMYCIN.

Authors:  M HORI; T TAKITA; G KOYAMA; T TADEUCHI; H UMEZAWA
Journal:  J Antibiot (Tokyo)       Date:  1964-05       Impact factor: 2.649

2.  Studies on formycin and formycin B in cells of Ehrlich carcinoma and E. coli.

Authors:  H Umezawa; T Sawa; Y Fukagawa; I Homma; M Ishizuka
Journal:  J Antibiot (Tokyo)       Date:  1967-11       Impact factor: 2.649

3.  Stereochemical analysis of the specificity of pancreatic RNAse with polyformycin as substrate: differentiation of the transphosphorylation and hydrolysis reactions.

Authors:  D C Ward; W Fuller; E Reich
Journal:  Proc Natl Acad Sci U S A       Date:  1969-02       Impact factor: 11.205

4.  Biological action of inosine analogs in Leishmania and Trypanosoma spp.

Authors:  J J Marr; R L Berens; N K Cohn; D J Nelson; R S Klein
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191

5.  The purine metabolism of protozoa.

Authors:  G H Hitchings
Journal:  Adv Enzyme Regul       Date:  1982

6.  Influence of formycin B on polyadenosine diphosphoribose synthesis in vitro and in vivo.

Authors:  W E Müller; H J Rohde; R Steffen; A Maidhof; M Lachmann; R K Zahn; H Umezawa
Journal:  Cancer Res       Date:  1975-12       Impact factor: 12.701

7.  Cultivation of Pneumocystis carinii with WI-38 cells.

Authors:  M S Bartlett; P A Verbanac; J W Smith
Journal:  J Clin Microbiol       Date:  1979-12       Impact factor: 5.948

8.  Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.

Authors:  R I Glazer; L S Lloyd
Journal:  Biochem Pharmacol       Date:  1982-10-15       Impact factor: 5.858

9.  Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.

Authors:  F M Gordin; G L Simon; C B Wofsy; J Mills
Journal:  Ann Intern Med       Date:  1984-04       Impact factor: 25.391

Review 10.  Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae.

Authors:  J J Marr; R L Berens
Journal:  Mol Biochem Parasitol       Date:  1983-04       Impact factor: 1.759
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  6 in total

1.  Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.

Authors:  S F Queener; M S Bartlett; M A Jay; M M Durkin; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

2.  A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents.

Authors:  M T Cushion; F Chen; N Kloepfer
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

3.  Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

Authors:  P D Walzer; C K Kim; J Foy; M J Linke; M T Cushion
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

4.  Total cellular fatty acid composition of cultured Pneumocystis carinii.

Authors:  J R Paulsrud; S F Queener; M S Bartlett; J W Smith
Journal:  J Clin Microbiol       Date:  1993-07       Impact factor: 5.948

5.  Comparative study of antipneumocystis agents in rats by using a Pneumocystis carinii-specific DNA probe to quantitate infection.

Authors:  P A Liberator; J W Anderson; M Powles; L A Pittarelli; M Worley; M Becker-Hapak; D C Graves; D M Schmatz
Journal:  J Clin Microbiol       Date:  1992-11       Impact factor: 5.948

6.  Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii.

Authors:  M S Bartlett; T D Edlind; M M Durkin; M M Shaw; S F Queener; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191
  6 in total

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