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Literature DB >> 34894129

Safety and Pharmacokinetics of Exebacase in an Infant With Disseminated Staphylococcus aureus Infection.

Ganga S Moorthy¹, Rachel G Greenberg^1,2, Chi D Hornik^1,2, Cara Cassino³, Parviz Ghahramani⁴, Karan R Kumar^1,2, Vance G Fowler^1,2, Michael Cohen-Wolkowiez^1,2.

Abstract

Exebacase, an antistaphylococcal lysin produced from a bacteriophage-encoded gene, is a promising adjunctive therapy for severe methicillin-resistant Staphylococcus aureus infections. We describe the first infant to receive exebacase, dosing, and pharmacokinetics. Exebacase may be safe and efficacious in children; however, further clinical trials are needed to optimize dosing.

Entities: Chemical

Keywords: bacteriophage-derived therapy; endocarditis; exebacase; methicillin-resistant Staphylococcus aureus

Mesh：

Substances：

Year: 2022 PMID： 34894129 PMCID： PMC9410717 DOI： 10.1093/cid/ciab1015

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 20.999

9 in total

Review 1. Methicillin-resistant Staphylococcus aureus therapy: past, present, and future.

Authors: Keith A Rodvold; Kevin W McConeghy
Journal: Clin Infect Dis Date: 2014-01 Impact factor: 9.079

2. The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis.

Authors: Chiara Indiani; Karen Sauve; Assaf Raz; Wessam Abdelhady; Yan Q Xiong; Cara Cassino; Arnold S Bayer; Raymond Schuch
Journal: Antimicrob Agents Chemother Date: 2019-03-27 Impact factor: 5.191

3. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children.

Authors: Catherine Liu; Arnold Bayer; Sara E Cosgrove; Robert S Daum; Scott K Fridkin; Rachel J Gorwitz; Sheldon L Kaplan; Adolf W Karchmer; Donald P Levine; Barbara E Murray; Michael J Rybak; David A Talan; Henry F Chambers
Journal: Clin Infect Dis Date: 2011-01-04 Impact factor: 9.079

Review 4. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.

Authors: Nicholas A Turner; Batu K Sharma-Kuinkel; Stacey A Maskarinec; Emily M Eichenberger; Pratik P Shah; Manuela Carugati; Thomas L Holland; Vance G Fowler
Journal: Nat Rev Microbiol Date: 2019-04 Impact factor: 60.633

5. Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis.

Authors: Vance G Fowler; Anita F Das; Joy Lipka-Diamond; Raymond Schuch; Roger Pomerantz; Luis Jáuregui-Peredo; Adam Bressler; David Evans; Gregory J Moran; Mark E Rupp; Robert Wise; G Ralph Corey; Marcus Zervos; Pamela S Douglas; Cara Cassino
Journal: J Clin Invest Date: 2020-07-01 Impact factor: 14.808

1 in total

Review 1. Phage Products for Fighting Antimicrobial Resistance.

Authors: Yuanling Huang; Wenhui Wang; Zhihao Zhang; Yufeng Gu; Anxiong Huang; Junhao Wang; Haihong Hao
Journal: Microorganisms Date: 2022-06-30