Modeling of Enzyme-FET Biosensor Based on Experimental Glucose-Oxidase Receptor.

The modeling of biosensors is useful in the design stage. The main device simulator, like Silvaco, has poor software resources for bio-receptors simulations. The modeling is challenging due to the high complexity of the living matter. It requires complementary knowledge from biochemistry, biosensors technology and electronic devices, like FET - Field Effect Transistors. This paper presents an analytical model for the product concentrations versus the time for enzymatic FET based on zero, one or two-order reaction. The mathematical model is confronted with an experimental model tested on a glucose biosensor that uses glucose-oxidase receptor enzyme. The biosensor response time was 36 seconds for enzyme loading of 2μmol/l.Clinical Relevance- The analytical model proposed in this paper represents an analytical tool in the design stage, for any biosensor used in clinical practices. Their modeling is missing.